喹啉类荧光染料的合成研究

摘要在溶液中，溶剂会影响有机分子的物理性质以及化学性质。尽管人们在溶剂效应方面的研究已超过一个世纪，但其影响规律依然难于理解，更难以预测。经过设计特殊的分子结构，大量溶致变色荧光染料被合成出来，作为一种能够定量测定溶液性质的指示剂，其在各领域得到广泛应用。88748

本论文研究了用喹啉酰胺等喹啉类衍生物作为底物，在用溴化钠试剂进行加溴后，用一系列试剂分别进行偶合反应，合成所需要喹啉类荧光染料，并对他们分别进行溶致变色性质的测定以及分析。具体内容如下：首先通过对溶致变色染料分子结构、设计思路、合成方法及溶剂化变性能综述，用苯环喹啉酰胺、呋喃环喹啉酰胺以及四氢呋喃环喹啉酰胺分别在喹啉环5号位用NaBr在醋酸铜、三甲基乙酸催化作用下进行上溴。其次，分别用4-氯苯乙炔、对硝基苯乙炔、4-乙炔基-N，N-二甲基苯胺、甲基苯乙炔醚、对氨基苯乙炔、对乙基苯乙炔进行偶联反应，过程中实验操作简单，反应控制条件少且温和，转化率高，反应结束后，用水洗涤反应液进而进行分离，实验操作简单。

In the solution, the solvent will affect the physical properties of organic molecules and chemical properties。 Although the study of solvent effects has been for more than a century, its influence is still difficult to understand and more difficult to predict。 After designing a special molecular structure, a large number of luminescent dyes are synthesized and used as an indicator for quantitatively determining the properties of the solution, which is widely used in various fields。

In this paper, quinoline derivatives such as quinoline amide were used as substrates。 After bromination with sodium bromide reagent, the coupling reaction was carried out with a series of reagents, and the quinolone fluorescent dyes were synthesized。 Respectively, the determination of lytic discoloration properties and analysis。 The main contents are as follows: Firstly, the molecular structure, design ideas, synthesis methods and solvating properties of the lysed dyestuffs were reviewed。 The reaction of phenoxyquinoline amide, furan ring quinolinamide and tetrahydrofuran ring quinolinamide were carried out in quinoline ring 5 The use of NaBr in copper acetate, trimethyl acetic acid catalysis on the bromine。 Second, respectively, with 4-chlorophenyl acetylene, p-nitrophenyl acetylene, 4-ethynyl-N, N-dimethyl aniline, methyl phenyl acetylene ether, p-aminophenylene acetylene, p-ethyl benzene acetylene coupling reaction , The process of simple operation, the reaction control conditions are small and mild, high conversion rate, after the end of the reaction, washing the reaction solution with water and then separation, the experimental operation is simple。源Q于D优G尔X论V文Y网wwW.yOueRw.com 原文+QQ75201`8766

毕业论文关键词：喹啉衍生物；荧光染料；溶致变色

Keyword: quindoline derivatives； fluorescent dye；solvatochromism

引言 4

1。实验背景概述6

1。1 荧光染料的性质与应用 ·6

1。2 荧光染料的结构与性能 ·6

2。实验部分8

2。1 实验试剂和仪器·8

2。1。1 实验仪器·8

2。1。2 实验试剂·8

2。2 实验过程·8

2。2。1 喹啉酰胺的制备·8

2。2。2 5-溴喹啉酰胺的制备·9

2。2。3 喹啉酰胺系列荧光染料的制备·9

2。2。4 2-呋喃喹啉酰胺的制备11 喹啉类荧光染料的合成研究:http://www.youerw.com/huaxue/lunwen_167421.html