摘要：本实验采用的是在水相中发生的化学反应。用环保又清洁的反应介质来代替常规的有机溶剂。响应绿色化学所提出的环境无害的概念。对比了亚硫酰氯氯化剂、三甲基氯硅烷氯化剂、N-氯代异丙胺氯化剂、N-氯代丁二酰亚胺氯化剂、三甲基氯硅烷氯化剂和三氯异氰尿酸的优缺点。并阐述了选用三氯异氰尿酸的理由。24501
探讨了在盐酸催化下的水-酯混合体系中，发生一氯代反应的反应条件。以及对反应条件的优化。并尝试着将其应用在其他苯乙酮类化合物的一氯代反应中，研究改变反应底物与产率的影响。通过控制变量的方法，寻找在盐酸催化下的水-酯混合体系中，发生二氯代反应的最佳反应条件。尝试选择了在对位添加卤素或者甲基等4种不同的苯乙酮类底物在二氯代反应中对产率的影响。24501
毕业论文关键词：水-酯混合溶剂；α-一氯代苯乙酮；α， α-二氯代苯乙酮；绿色化学；
Selectivity of the chlorinated water - ester mixture system  under Hydrochloric acid about A chlorinated reaction and two chlorinated reaction
Abstract: This experiment adopts the reaction of the chemicals in the water phase. With environmental protection and clean reaction medium instead of conventional organic solvents. Response of green chemistry, put forward the concept of environmental friendly.Compared with thionyl chloride chlorinating agent, trimethyl chlorosilane chlorinating agent, N - chlorinated chlorinating agent, N - isopropyl amine chlorinated butyl diimide chlorinating agent, agent of trimethylchlorosilane chlorination and cross-linked with different advantages and disadvantages of cyanuric acid. And expounds the selection of high-intensity different reasons for cyanuric acid.
In this paper ,we explored chlorine substitution reaction condition of acetophenones with HCl as catalyst in water-ester mixed dissolvent system and optimized reaction condition. Bisides, other α-chlorinated acetophenones analogues were synthesed under the optimal conditions .The variation on reaction substrate and yield of products obtained is studied as well.By controlling variables, Searched the best condition of dichlorine substitution reaction  of acetophenones with HCl  as catalyst in water-ester dissolvent mixed system. The effects of acetophenones with opposite-substituted by different kinds of halogen or methyoxy on the yield of dichlorine  substituted  acetophenones were studied.
Key words: water-ether solvent ; α-chlorinated acetophenones；α，α-dichlorinated acetophenones;  green chemisty;
目录
1 绪论    1
1.1水相中的绿色化学    1
1.2各种氯代试剂的优缺点    1
1.2.1 各类氯代试剂的类别    1
1.2.1.2亚硫酰氯氯化剂    1
1.2.1.2 N-氯代异丙胺氯化剂    3
1.2.1.3 N-氯代丁二酰亚胺氯化剂    3
1.2.1.4 三甲基氯硅烷氯化剂    4
1.2.1.5 三氯异氰尿酸    4
2 水盐酸催化下的、水-酯混合体系中的选择性一氯代反应与二氯代反应    5
2.1盐酸催化下的、水-酯混合体系中的选择性一氯代反应条件优化    5
2.1.1 结果与讨论    5
2.1.2 实验部分    8
2.2 盐酸催化下的、水-酯混合体系中的选择性一氯代反应底物拓展    10
2.2.1 结果与讨论    10
2.2.2 实验部分    12
2.3盐酸催化下的、水-酯混合体系中的选择性二氯代反应条件优化    15
2.3.1结果与讨论    15
2.1.2 实验部分    19
2.4 盐酸催化下的、水-酯混合体系中的选择性二氯代反应底物拓展    21 盐酸催化下的水-酯混合体系中的选择性氯代反应与二氯代反应:http://www.youerw.com/huaxue/lunwen_18027.html