摘要绿色化学己成为当前化学研究的热点和前沿，它旨在从源头上减少或消除污染。离子液体由于其独特的性能和受到高度的关注而成为绿色化学研究的热门。但是其也有粘度过大、用量过多、价格昂贵、易流失等缺陷，为了解决这些问题，负载型离子液体出现在人们的视线中。
多组分反应是近年来快速发展起来的一种连续、简便、高效的合成方法和绿色合成途径，特别是实现快速、大量地合成具有结构多样性和复杂性的化合物，用于优化和筛选具有药理活性的前导化合物，越来越引起了化学和药物学工作者的极大兴趣。8308
本文研究了负载离子液体催化剂催化的曼尼希反应。合成了新型硅胶负载离子液体催化剂AIL@SiO2 ,用红外以及核磁的方法确定其结构，通过热重的方法确定其负载率可达21%。采用了简单地醛、酮、胺的三组分曼尼希反应作为研究的对象，研究了硅胶负载离子液体对曼尼希反应的催化效应以及回收性。研究证明，该催化剂对反映有一定的催化效应，并可以循环使用至少四次而不降低其催化效果。
关键字：硅胶负载离子液体，曼尼希反应，循环使用，AIL@SiO2
毕业设计说明书（论文）外文摘要
Title Multi-component reactions catalyzed by the silica-supported ionic liquid
Abstract
Green chemistry, which aims to eliminate the pollution, is becoming the hotspot and the foreland in chemical research. Ionic liquid is subjected to a high degree of attention and become a hot research because of its unique performance. But its viscosity is too large, excessive amount of expensive, easy loss of defects, in order to solve these problems, the supported ionic liquid in the people's attention.
In recent years，multi—component reactions(MCRs)，which response to the rapid development of an easy，successive，efficient synthetic method and green chemistry．Because it can rapidly synthesize large numbers of structural persity and complexity compounds to optimize and screen for pharmacological activity Precursors．
This paper studies the Supported Ionic Liquid Catalyst for the Mannich reaction. The AIL@SiO2 that is a new silica gel supported ionic liquid catalyst was synthesized. IR and NMR was used to determine its structure, and thermal gravimetric was used to determine its load rate up to 21%。 The activity and recycling of the catalyst was investigated through one-pot three-component Mannich-type reactions of aldehydes, amines and ketones. Studies showed that the catalyst have a catalytic effect and could be reused at least four times without reducing its catalytic effect.
Keywords Silica-supported ionic liquid, Mannich reaction, recycling, AIL@SiO2
目录
1 绪论 1
1.2 离子液体简介 1
1.1.1 离子液体研究发展 1
1.1.2 离子液体的种类和性质 2
1.1.3 离子液体在合成中的应用 3
1.2 多组分反应 4
1.2.1 多组分反应发展简介 4
1.2.2 曼尼希反应发展 6
1.2.3 曼尼希反应的应用 6
1.3 固载化催化剂 7
1.3.1 浸渍法 8
1.3.2 键合法 8
1.3.3 溶胶-凝胶法 8
1.4 本课题研究的目的与内容 8
2 硅胶负载离子液体的合成与表征 9
2.1 概述 9
2.2 实验部分 9
2.2.1 实验药品和仪器 9
2.2.2 硅胶负载催化剂的合成 10
2.3 硅胶负载催化剂的表征 12
2.3.1 负载前离子液体的核磁谱图 12 硅胶负载离子液体催化的多组分反应:http://www.youerw.com/huaxue/lunwen_6589.html