摘要抗癌药物在临床应用中因为不能准确作用病变部位，不仅药效低下，而且会在正常部位作用造成副作用，对身体造成危害。本文通过合成Fe3O4@mSiO2并对其进行一系列改性并与β-环糊精络合，组建成双重刺激-响应型智能纳米容器并使用TEM，FT-IR，核磁，质谱等手段对其进行一系列表征检测。这样的纳米容器能通过响应磁场刺激信号使药物富集在一定区域，并且能响应环境酸碱值变化，在酸性条件中对包裹药物进行释放，这样的纳米容器运用在医药学中能很好提高抗癌药的药效和减少副作用。在模拟释放试验中，使用BTA作为吸附对象并对其释放，证明产物对药物有一定封装作用并且保留很好的磁性。73341

毕业论文关键词  可控释放  纳米容器  超分子化学 

毕业设计说明书外文摘要

Title        Study on smart stimuli-responsive nanocarriers       

Abstract In clinical applications, because of anticancer drugs can not accurately effect the site, that would not only low efficacy, but also do harm to the body。 In this paper, through the synthesis of Fe3O4 @ mSiO2 and the carried out a series of modified and with beta cyclodextrin complex, the formation of a smart stimulus - response nanocarrier and using TEM, FT-IR, NMR, MS and other measurements to make a series of characterization。 Such a nanocarrier can not only response to field stimulation signal and concentrate in a certain region, but also response to pH changes。 In the acidic conditions of the encapsulated drug release, such nanocarriers using in medicine can improve the efficacy of anticancer drugs and reduce side effects。 In the simulated release test, the BTA was used as the adsorbent and its release, the result proved that the product has a certain encapsulation effect and retains a good magnetic response ability。 

Keywords  controlled release   nanocarriers   supramolecular chemistry

目   次

1  绪论 1

1．1  超分子化学 1

1．2  主客体化学 1

1．3  大环分子-环糊精 2

1．4  介孔材料 3

1．5  药物控释 3

1．6  本课题的研究意义与主要内容 5

2  刺激-响应型智能纳米容器的制备 6

2．1  Fe3O4纳米颗粒的合成与表征 6

2．2  Fe3O4@mSiO2纳米颗粒的合成与表征 9

2．3  2-氯甲基苯并咪唑的合成与表征 12

2．3  Fe3O4@mSiO2纳米颗粒表面有机功能化 16

3  pH刺激-响应实验及分析 20

3．1  实验仪器 20

3．2  实验药品 20

3．3  BTA最大释放量的检测 20

3．4  中性条件小BTA的释放 23

3．5  酸性条件下BTA的释放 23

3．6  实验结论 23