羟丙基壳聚糖/聚乙烯醇膜的制备及性能研究

摘要壳聚糖和聚乙烯醇都具有优越的生物学性能，因此它们被广泛地应用于生物工程领域。同时，它们之间具有良好的相容性和互补性，因而它们的共混研究一直都是个热点。为了找出影响共混膜性能的关键因素，优化制备工艺，得到性能更佳的共混膜材料，拓宽其在生物医学工程领域的应用前景。本论文对羟丙基壳聚糖和聚乙烯醇的共混进行了研究。83142

本论文先以壳聚糖为原料制备得到羟丙基壳聚糖，然后将羟丙基壳聚糖与聚乙烯醇共混制备成膜，并通过不同的方法对产物羟丙基壳聚糖以及共混膜进行了结构表征和性能测试。论文分别研究了反应温度（15℃，30℃、45℃、60℃）对羟丙基壳聚糖制备的影响；交联方式（反复冻融法，交联剂戊二醛和 1,4-丁二醇二缩水甘油醚）对共混膜性能的影响；交联剂用量(羟丙基壳聚糖与聚乙烯醇总摩尔数的 0。5%、1%、2%、 3%和 4%)对共混膜性能的影响；两组分质量配比（羟丙基壳聚糖与聚乙烯醇的质量比分别为 4:1、2:1、1:1、1:2 和 1:4）对共混膜性能的影响。

实验结果表明，羟丙基壳聚糖的最佳制备温度为 45℃，在此温度下反应时间较短，制备得到的产物粘度相对较大，溶解度较高。羟丙基壳聚糖与聚乙烯醇共混的最佳质量比为 1:2，最适合的交联剂为 1,4-丁二醇二缩水甘油醚，而交联剂最佳用量为两组分总摩尔数 2%，在此条件下，制备得到的共混膜综合性能最优。

毕业论文关键词：羟丙基壳聚糖；聚乙烯醇；共混膜；交联

Abstract Chitosan and polyvinyl alcohol are widely used in bioengineering owe to their superior biological properties。 At the same time, they have good compatibility with each other。 Thus, the blending of the two materials is a hot topic。 In order to find the key influencing factors of the blend membranes and optimize the preparation technology and finally broaden its application prospects in bioengineering。 This thesis researched the blending of hydroxypropyl chitosan and poly(vinyl alcohol)。

This thesis prepared hydroxypropyl chitosan with chitosan and then blended it with poly(vinyl alcohol) to prepare blend membranes。 Finally, raw materials and these blend membranes were characterized through different characterization methods。 This thesis mainly researched the impact of temperature (15℃, 30℃, 45℃, 60℃) on hydroxypropyl chitosan preparation and the impact of crosslinking methods(freeze-thaw cycles，glutaric dialdehyde，1,4-Butanediol diglycidyl ether), the amount of crosslinking agent (0。5%, 1%, 2%, 3%, 4% of the two materials’ mole number), mass ratio of the two raw materials (the ratio of HPCS and PVA is 4:1, 2:1, 1:1, 1:2 and 1:4) on the blend membranes。

The results indicate that the optimum temperature is 45℃, under this temperature, the

time of the reaction is shorter and the production has higher viscosity and solubility。 The most suitable crosslinking agent is 1,4-butanediol diglycidyl ether and its amount is 2%, the best mass ratio is 1:2。 Under these conditions, the blend membrane has the best combination property。

Keywords: Hydroxypropyl chitosan；poly(vinyl alcohol)；blend membrane； crosslinking

第一章绪论１

1。1 壳聚糖及其衍生物１

1。1。1 甲壳素和壳聚糖１

1。1。2 壳聚糖的特性１

1。1。3 壳聚糖的应用１

1。1。4 壳聚糖目前的研究重点２

1。2 聚乙烯醇羟丙基壳聚糖/聚乙烯醇膜的制备及性能研究:http://www.youerw.com/cailiao/lunwen_97842.html