摘要: 近年来，核壳结构的纳米材料特别是金纳米核倍受关注。由金纳米核和绝缘体壳组成的复合纳米颗粒，具有高度可调的光学性质以及良好的生物相容性等优点，因此在在生命科学、环境监测、食品安全等很多领域有着广阔的应用前景，但是，金纳米颗粒本身存在稳定性较差等一些局限性，当在其表面包裹一层绝缘的SiO2，同时获得理想的表面增强拉曼散射，更能进一步拓展其在生物医学领域的应用。基于此，本论文研究制备了稳定性好，包覆均匀并且有良好的拉曼散射的Au@SiO2。首先先采用Frens方法用柠檬酸钠还原氯金酸获得金溶胶（Au NPs），再使用正硅酸乙酯（TEOS）和硅酸钠水溶液两种前驱体分别对金胶包覆二氧化硅。通过改变前驱体的加入量和反应时间来制备包覆不同厚度的二氧化硅壳层的Au@SiO2。该论文对进一步制备可控制二氧化硅壳层厚度的金胶包覆核-壳结构提供了一定的参考。23275
毕业论文关键词： 表面增强拉曼光谱(SERS)；Au@SiO2；金纳米颗粒；二氧化硅壳
Synthesis and Characterization of
Au@SiO2 core-shell colloids
Abstract: In recent years, core-shell structure of the metal shell particularly gold nanoshells attracted much attention. This gold shell and the insulator core consisting of composite nanoparticles has broad application prospects in many areas of drug delivery, medical imaging and cancer treatment, and tissue repair. Because of their height-adjustable optical properties and good biocompatibility. However, due to some limitations of the gold shell, wrapped in a thin layer on the surface of SiO2 may be beneficial to the further application of the gold shell. If you can get a good surface Raman scattering, it will greatly expand the Au @SiO2 applications in the biomedical field. Therefore, this paper was prepared a good stability, good coating uniformity and Raman scattering of Au@SiO2. First use Frens method to restore the acid chloride with sodium citrate to obtain gold Au NPs, then use TEOS and sodium silicate precursors as two gold -coated silica gel. By controlling the amount of precursor and the reaction time to prepare the silica shell of different thickness. The paper provides a reference for further preparation of controling the thickness of the Au@SiO2 core-shell structure.
Keywords： Surface Enhanced Raman Spectroscopy (SERS); Au@SiO2; Au NPs; Silica shell
目录
1 前言 1
1.1 金属纳米材料 1
1.1.1 纳米材料的简介 1
1.1.2 金纳米颗粒 1
1.2 核壳纳米材料 3
1.3 表面增强拉曼散射（SERS）的介绍 3
1.3.1 SERS的现象和原理 4
1.3.2 SERS光谱的应用研究 4
1.4 纳米材料的表征 5
1.5 课题的研究目的和意义 6
2 实验部分 7
2.1 试剂与仪器 7
2.1.1 试剂 7
2.1.2 仪器 7
2.2 实验步骤 7
2.2.1 试剂的配制 7
2.2.2 金纳米颗粒的制备 8
2.2.3 TEOS为硅源的Au@SiO2的制备 8
2.2.4 硅酸钠为硅源的Au@SiO2的制备 8
2.2.5 紫外-可见吸收光谱测试 9
2.2.6 表面拉曼光谱测试 9
2.2.7 TEM表征 9
3 实验结果与讨论 10
3.1 金纳米颗粒的表征 10
3.2 Au@SiO2的表征 11
3.2.1 TEOS作为硅源的Au@SiO2的制备原理 11
3.2.2 硅酸钠作为硅源的Au@SiO2 13
3.2.3 Au@SiO2的SERS光谱表征 15 Au@SiO2的合成及表征+文献综述:http://www.youerw.com/huaxue/lunwen_16267.html