磺胺甲恶唑分子印迹聚合物的制备及其吸附性能研究

摘要磺胺甲恶唑是一种广谱抗生素，是多种兽医用药的主要成分。随着医疗技术的快速发展，磺胺类药物被广泛的应用于人体及养殖业。长期接触被污染的水体会使人体对抗生素药物产生抗体，危害人体健康。如何有效检出和治理被抗生素污染的水域是当今至关重要的问题。本文采用非共价键法，以 Stober 法制备的 SiO2 做载体制备磺胺甲恶唑分子印迹聚合物并对其吸附性能进行研究。以磺胺甲恶唑（SMO）为模板分子，选用甲基丙烯酸（MAA）为功能单体，硅胶为载体，乙二醇二甲基丙烯酸酯（EGDMA）为交联剂，偶氮二异丁腈（AIBN）为引发剂，在 60℃水浴氮气保护下合成表面分子印迹聚合物（SMIP）。优化了功能单体及交联剂的比例、二氧化硅投加量等条件，在最优条件下合成 SMIP。利用扫描电镜（SEM）、热重分析（TGA）、傅里叶变换红外光谱(FT-IR)等对 SMIP 的形态结构进行表征分析。 SEM 表征结果显示 SMIP 负载在硅球表面，二氧化硅的粒径为 100-150nm，TGA 分析结果表明 SMIP 可承受 250℃左右的高温。研究了 pH 对 SMIP 的吸附量的影响，结果表明 pH 值越小吸附量越大。并对 SMIP 的吸附动力学、吸附等温线、特异性吸附等吸附性能进行了研究，结果表明吸附平衡时间为 10 分钟，吸附速率用准二级吸附动力学模型分析，吸附等温线可用 Freundlich 模型分析，SMIP 对 SMO 及其类似物的选择性吸附研究表明 SMIP 对 SMO 具有特异性吸附功能。81711

毕业论文关键词：Stober 法；表面分子印迹；吸附；特异性吸附

Abstract Sulfamethoxazole is a kind of broad-spectrum antibiotic, which is a major ingredient of various veterinary drug。 Long-term exposure to polluted water weakens immunity and harms body health。 It is a issue of crucial importance to effectively detect and treat antibiotic-polluted water。

This article used non covalent binding method to research the preparation and adsorption ability of SMIP used silica prepared with Stober method。 This surface molecularly imprinted polymer was prepared under 60℃water bath and in nitrogen

protection condition with Sulfamethoxazole（SMO）as template molecule，methacrylic

acid （ MAA ） as functional monomer ， silica gel as carrier ， ethyleneglycol dimethacrylate（EGDMA）as cross-linking agent，2-methylpropionitrile(AIBN) as initiator。 This research optimized conditions as functional monomer ratio ，

cross-linking agent dosage，silica dosage, and prepared SMIP under optimal condition。 SEM, TGA, FT-IR were used to characterization SMIP’ morphostructure。 SEM characterization shows the SMIP were loaded on the surface of silica microspheres， the diameter of silica microspheres was around 100-150nmm，TGA shows SMIP can withstand high temperature around 250℃。 The influence of pH to the SMIP

adsorption capacity has been studied ， the result shows the capacity is inversely proportional to pH。 other adsorption abilities such as adsorption dynamics, adsorption isotherm and specific adsorption were evaluated as well，the result shows adsorption equilibrium time is 10 min, the adsorption dynamics can be described by the

Pseudo-second-order model, the adsorption isotherm can be described by Freundlich model, SMIP has specific adsorption to SMO。

Keywords: Stober method; surface molecularly imprinted polymer; adsorption; specific adsorption。

第一章绪论磺胺甲恶唑分子印迹聚合物的制备及其吸附性能研究:http://www.youerw.com/huaxue/lunwen_95602.html