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摘要本文以缬氨酸和4-吡啶甲醛为原料，通过席夫碱和还原反应制备了N-（4-吡啶甲基）-L-缬氨酸乙酸钠（L-VA），并以L-VA为配体，锌为中心原子制备了相应的金属有机凝胶因子。该凝胶因子能够在水中自组装形成超分子凝胶，文中制备的两种超分子凝胶的临界凝胶浓度（MGC）分别为80gL-1和90gL-1，溶胶-凝胶转变温度分别为48±1℃和50±1℃。同时，该凝胶材料表现出可逆的不透明-透明相转变性质。此外，通过L-VA与1,12- 二氨基十二胺的缩合反应制备了十二亚甲基-1,12-双（N-（4-吡啶甲基）-L-缬氨酸）（LL-12VA），LL-12VA同样能够与锌离子配位形成超分子凝胶。以上工作有助于揭示超分子金属水凝胶自组装的特征和规律性，为进一步研究和开发刺激响应性超分子凝胶材料提高了基础。28876
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关键词 缬氨酸 超分子 金属水凝胶 配位
毕业论文设计说明书外文摘要
Title Preparation and characterization of the thermo-sensitive
supramolecular gels
Abstract
In this paper, N- (4-pyridylmethyl) -L- valine sodium acetate (L-VA) were synthesized by Schiff base and reduction reaction in which L-valine and 4-pyridinecarboxaldehyde as materials. The metal organic gelator was prepared with L-VA as the ligand and zinc as the center atom. The gelator is capable of forming supramolecular gels by self-assembly in water, and the critical gelation concentration (CGC) of opaque ZAVA and ZNVA hydrogel was 80g L-1 and 90g L-1, respectively; and the gel-to-sol transition temperatures (Tgel) were 48±1℃and 50±1℃, respectively.The hydrogels were thermoreversible which displayed an unprecedented (opaque gel)-to-(transparent gel) transition. In addition, the twelve methylene -1,12- double (n - (4 - methyl pyridine) - L - valine) LL-12VA were synthesized by the condensation reaction of L-VA and 1,12-Dodecanediamine, and LL-12VA can also form supramolecular gels with the zinc ions. The work above can help to reveal the characteristics and regularity of supramolecular metal hydrogel self-assembly, and to improve the basic of the research and development of the stimulation responsive supramolecular gel materials.
Keywords L-Valine; Supramolecular; Metallogels; Coordination.
目 次
1 绪论 1
1.1 超分子凝胶 1
1.1.1 概述 1
1.1.2 超分子凝胶的分类 2
1.1.3 超分子凝胶的应用 3
1.1.4 超分子凝胶的制备与表征 5
1.2 超分子金属凝胶 6
1.2.1 超分子金属凝胶的定义 6
1.2.2 超分子金属凝胶的类型 6
1.2.3 超分子金属凝胶的应用 7
1.3 本文的目的与意义 9
2 N-（4-吡啶甲基）-L-缬氨酸乙酸钠及其金属超分子凝胶的制备 10
2.1 引 言 10
2.2 实验部分 10
2.2.1 实验药品 10
2.2.2 表 征 11
2.2.3 金属超分子水凝胶的制备 11
2.3 结果与讨论 13
2.3.1 红外光谱分析 13
2.3.2 核磁共振波谱（1H-NMR）分析 14
2.3.3 不透明-透明凝胶相转变 15
2.3.4 其他氨基酸配体凝胶性能的探索 16
2.4 小 结 17
3 十二亚甲基-1,12-双（N-（4-吡啶甲基）-L-缬氨酸）及其金属超分子凝胶的制备 18
3.1 引 言 18