异常糖链糖蛋白检测TAP检测技术的应用

摘要：肿瘤的早期发展是一个可以双向转化的动态过程，亚临床期是肿瘤防治的关键：亚临床期肿瘤细胞数通常在108以内，可逆发展阶段，此时的肿瘤组织是脆弱的，肿块周围尚未形成血管，如果可以早期干预治疗，则可以消除癌细胞，是身体变得健康。目前临床常用的肿瘤标志物，敏感度和特异性低、可检测的肿瘤种类少，用于肿瘤的早期发现存在一定的困难。异常糖链糖蛋白检测（TAP）检测的敏感度和特异性高、可检测的肿瘤种类多，高达四十几种，TAP检测结合现有各种影像，临床等检查手段，可尽最大可能早期发现肿瘤！TAP用于肿瘤早期筛查，浓缩肿瘤高危人群，成功解决亚临床期肿瘤的诊断问题，对肿瘤防治具有重大的现实意义。54355

毕业论文关键词：异常糖链糖蛋白，肿瘤，疾病，凝集反应，TAP检测

Abstract：Early development of cancer is a two-way dynamic process of transformation, subclinical cancer prevention is the key: the number of subclinical tumor cells usually within 108, is still in a reversible stage of development, this time the tumor tissue is fragile, yet around the lump the formation of blood vessels by improving immune function, it is easy to "wipe out" in the bud. Commonly used in clinical tumor markers, the sensitivity and specificity is low, less detectable tumor types, for the early detection of tumors there are some limitations. TAP examination sensitivity and high specificity, tumor type can detect multi, TAP examination combined with existing inspection methods, can make the greatest possible early detection of cancer! TAP used for early cancer screening, cancer risk populations concentrated, diagnose problems successfully solved subclinical tumor is of great practical significance for cancer prevention.

Keywords: Abnormal glycoprotein sugar chains, tumor diseases, agglutination, TAP detected

1．前言 5

1.1 TAP检测项目引进和研发背景 6

1.1.1 TAP检测技术的发明背景 6

1.1.2 TAP检测技术的发明和引进 6

1.2 TAP检测的理论基础 7

1.2.1 糖基化与肿瘤 7

1.2.2 凝集素与异常糖链糖蛋白 7

1.3 TAP检测原理 8

2. TAP检测的临床应用与操作流程 10

2.1 TAP检测的临床应用 10

2.1.2 用于肿瘤的诊断 10

2.1.3 用于肿瘤患者疗效评估和患者复发转移动态监测及预后评估 11

2.1.4 结合其他检查，用于体检人群和病人的肿瘤筛查 11

2．2 TAP 检验步骤 11

3. 结果分析 12

3.1 TAP检测的技术特点和优缺点 12

3.1.1 TAP检测是一种组合肿瘤标志物的检测技术 12

3.1.2 TAP检测的优点 13

3.1.3 TAP检测的缺点 14

3.2 TAP检验结果 14

讨论 17

参考文献 18

致谢 20

1．前言

正如人们所知的那样，肿瘤是严重威胁人类健康的一种重大疾病，目前恶性肿瘤的发病率和死亡率逐年增高，我国每年恶性肿瘤新发病200多万例，死亡超过150万例，迄今为止，恶性肿瘤尚没有特效的治疗方法[ 11]。异常糖链糖蛋白检测TAP检测技术的应用:http://www.youerw.com/yixue/lunwen_58558.html