摘要：扑热息痛又称对乙酰氨基酚，是目前散热、镇痛、治感冒的常用药之一。本次设计涉及一种对乙酰氨基酚的合成工艺，特别涉及以对硝基苯酚为起始原料，通过钯/碳催化加氢及乙酰化合成对乙酰氨基酚(简称APAP)的工艺方法。对乙酰氨基酚的合成方法有很多种，对乙酰氨基酚的生产方法可以根据PAP和APAP的制备是否独立进行而分为一步法和两步法，但存在工艺复杂、收率低，能耗大，成本高等问题。本生产工艺技术解决方案如下：以对硝基苯酚为原料，以负载型的钯/碳催化剂加氢催化合成对氨基酚，再用醋酐酰化制备APAP。和现有技术相比，对PAP的选择性更高，简化了现有的生产工艺，收率提高，能耗降低，节约了成本以及减少了三废的产生。36067
毕业论文关键字：扑热息痛；对氨基苯酚；对乙酰氨基酚；工艺设计
Abstract
Acetaminophen, also known as paracetamol, it is one of the most commonly used drugs for the heat, pain, and colds. With the development of modern technology, the production process of anti-inflammatory drugs are constantly improving.There are many synthetic methods of acetaminophen, acetaminophen can be prepared according to the method of producing PAP and APAP whether it’s independent pided into one-step and two-step method, but there are some problems such as, complex process, low yield, high energy consumption and high cost. This design involves a kind of synthesis of acetaminophen, especially involving the process method of using the nitro phenol as a starting material, synthesis of acetaminophen(APAP) by palladium/carbon hydrogenation and acetylation. The production solutions are as follows: we use the nitro phenol as raw materials, supported palladium/carbon catalyst with hydrogen catalytic to synthesis of paracetamol, using acetic anhydride to acylated to prepare APAP. Compared with prior art, it’s a higher selectivity for PAP, simplifying the existing production process, increase yields, reducing energy consumption, saving costs and reducing waste generation.
Keywords: acetaminophen; p-aminophenol; acetaminophen;Process Design窗体底端
目录
摘 要 I
Abstract II
第一章 课题背景 1
1.1 课题来源 1
1.2 研究背景及意义 1
第二章 文献综述 2
2.1 引言 2
2.2 生产工艺路线比较 2
2.2.1 以苯酚为原料合成扑热息痛 2
2.2.2 以硝基苯为原料的合成路线 3
2.2.3 以对硝基苯酚钠为原料的路线 5
2.2.4 其他合成路线 5
2.2.5 本设计采用的合成路线 5
2.3 生产规模的确定 6
第三章 产品方案 7
3.1 产品名称与性质 7
3.2 性状及理化性质 7
3.3 产品的质量规格 7
3.4 产品的生产制度 7
3.5 包装与储藏 7
第四章 生产方法与主要工艺流程 8
4.1 生产方法 8
4.2 主要工艺流程 8
4.3 工艺过程说明 8
4.3.1 PAP的制备 8
4.3.2 APAP的初制 9
4.3.3 APAP的精制 9
第五章 生产工艺控制和中间体质量标准 10
5.1 生产工艺控制 10 年产500吨扑热息痛的生产工艺设计:http://www.youerw.com/huaxue/lunwen_34377.html