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摘要摄入适量的奖赏性食物可能会为缓解低氧应激反应提供一条简便有效的新途径。因此，本实验以SD雄性大鼠为实验对象，采用密闭减压舱模拟5000米海拔处低氧环境，利用高架十字迷宫实验与旷场实验检测SD雄性大鼠的焦虑行为及活动量，探讨奖赏性食物对低氧暴露大鼠应激行为的影响。46699

实验结果：

1.与对照组C（饲料/水）相比，低氧暴露极显著降低低氧组H（饲料/水）大鼠体重、饲料摄入量及总能量摄入。与对照组SC（饲料/水/30%蔗糖溶液）相比，低氧暴露极显著降低低氧组SH（饲料/水/30%蔗糖溶液）大鼠体重、饲料摄入量，极显著增加总能量摄入。但低氧暴露前后，低氧组SH大鼠体重无显著差异。

2.与对照组相比，低氧暴露极显著增加低氧组SH/HH（饲料/水/0.1%糖精钠溶液）大鼠蔗糖/糖精钠摄入量。

3.在高架十字迷宫实验中，与低氧前相比，低氧暴露显著降低低氧组H大鼠开臂时长及开臂次数。而低氧组SH/HH大鼠与低氧前相比，开臂时长及开臂次数略有下降，差异不显著。并且，低氧暴露显著增加低氧组H大鼠在高架十字迷宫中的不动时长。而低氧组SH/HH大鼠在高架十字迷宫中的不动时长略有增加，差异不显著。

4.在旷场实验中，与低氧前相比，低氧暴露显著降低低氧组H大鼠外周跨线次数；降低外周时长，增加内跨线次数及内时长，但变化不显著。低氧暴露显著降低低氧组SH大鼠外周跨线次数；增加外周时长，降低内跨线次数及内时长，但变化不显著。低氧暴露显著降低低氧组HH大鼠外周跨线次数、外周时长，显著增加内跨线次数及内时长。与低氧前相比，低氧暴露极显著降低低氧组H/HH大鼠站立次数；降低低氧组SH大鼠站立次数，但变化不显著。

结论：

低氧暴露后，大鼠产生了明显的应激反应并对奖赏性食物更加偏好，增加了奖赏性食物的摄入。大鼠增加对奖赏性食物的偏好能有效的缓解低氧应激行为。在该过程中奖赏性食物的奖赏属性起到了主要的作用，奖赏性食物的能量属性可能也产生了一定的影响。两者间复杂的相互作用远比我们想象的更加复杂。因此，进一步的研究是必要的。

Abstract

Adequate intake of palatable foods might is a simple and effective new way for easing hypoxic stress responses. Therefore, this experiment, using SD male rats as experimental subjects and a closed vacuum chamber to simulate hypoxic environment at 3000 meters above sea level and the Elevated plus maze test and Open field test to detect the anxious behaviors and activities of SD male rats, investigates the effects of palatable foods to the stress behaviors of hypoxic rats.

Experimental Results:

1. Compared with the control group C(chow/water), hypoxic exposure significantly reduced body weight, food intake and total energy intake of hypoxic group H(chow/water) rats. Compared with the control group SC(chow/water/30%sucrose), hypoxic exposure significantly reduced body weight, food intake and increased total energy intake in the hypoxic group SH(chow/water/30%sucrose) rats. But, there is no significant difference with respect to body weight in the hypoxic group SH rats compared with the previous hypoxia.

2. Compared with the control group, hypoxic exposure significantly increased sucrose/saccharin intake in the hypoxic group SH/HH (chow/water/0.1%saccharin) rats.

3. In the Elevated plus-maze test, the open arm time and open arms entries were significantly reduced in the hypoxic group H rats compared with the previous hypoxia. The open arm time and open arms entries were a slight decrease in the hypoxic group SH/HH rats, the difference was not significant. And, hypoxic exposure significantly increased the elevated plus maze immovable time in hypoxia group H rats. The elevated plus maze immovable time was a slight increase in the hypoxic group SH/HH rats, the difference was not significant. (责任编辑：qin)