摘要本论文主要研究利用光的多普勒效应并结合光学相干断层层析术来对生物体表面组织实现非接触、无损伤、快速实时成像，并由此计算微循环中血流速度这一物理量。该技术的进一步完善并应用于医学成像领域，无疑将对一些心血管疾病的临床诊断提供很大程度的便利。首先用玻璃毛细管模拟人体毛细血管，对流动其中的溶液进行速度成像测量，然后依靠搭建光纤型迈克尔逊干涉光路对实验白鼠的耳朵表层进行成像；最后，利用matlab软件对所得实验数据进行了分析和计算，并对影响速度测量结果精确性的因素进行了分析。22007
关键词 多普勒效应，血液流速，医学成像，迈克尔逊干涉
毕业论文设计说明书（论文）外文摘要
Title Study of High-Resolution Blood Flow Velocity Imaging
with Optical Coherence Tomography
Abstract
In this thesis the main purpose is to use the combination of the optical Doppler effect with optical coherence tomography technology to image the surface tissue in vivo without contacting and damaging in real time. Based on the measured signals the velocity of blood flow in microcirculation was calculated. The improvements of this technology and applications in the field of medical imaging would definitely provide benefits in clinical diagnosis of some cardiovascular diseases. First of all glass capillaries were used to simulate blood capillaries in vivo and images of the velocity of solution flowing in them were obtained. The established fiber-optics Michelson interferometer-based OCT was used to image ear surface of experimental mouse. Finally the matlab software was used to calculate and analyze data acquired in experiments and factors which influence the accuracy of results of velocity measurement were analyzed.
Keywords Doppler effect ，velocity of blood flow ，medical imaging ，Michelson interferometer
目 次
1. 绪论 1
1.1 表层成像的医学意义 1
1.2 OCT技术发展历史 1
1.3 光学相干层析的优势 2
1.4 本课题拟解决的问题 2
1.5 本文各章的安排 3
2. OCT系统原理及数学模型 4
2.1 时域OCT 4
2.2 频域OCT 5
2.3 OCT性能指标 6
2.4 OCT测速原理 11
2.5 多普勒频移的获得 13
3. 实验系统的构成 14
3.1 光源选择 14
3.2 干涉系统 15
3.3 振镜系统 15
3.4 光谱分析结构 16
4. 实验结果分析 19
4.1 毛细玻璃管模拟活体实验 19
4.2 白鼠耳朵上表面成像 21
5. 影响因素分析 24
5.1 直流噪声 24
5.2 复共轭模糊像 25
5.3 色散影响 26
5.4 影响多普勒频移测量的因素 27
结 论 29
致 谢 30
参考文献31
附 录 34
1. 绪论
本章主要介绍本论文所涉及主要技术的发展，着重介绍其在医学领域内的实际应用，并阐述利用OCT技术测量微循环血液流速的基本原理，在最后总结本论文所要解决的主要问题和预期达到的目标。 matlab高分辨率血液速度光学断层成像研究:http://www.youerw.com/tongxin/lunwen_14462.html