摘    要健康问题一直是人们最为关心的问题，如何抵抗疾病就成了当今比较热门的话题和研究方向，同时也能很好地鼓励医学药物事业的发展。在医学药物这一领域当中，不少是采用化学合成的手段去制造新的药物产品。喹啉是较为重要的杂环，它的取代基在一定的取代位置上会具有特点的活性。比如，在第二位取代的喹啉是具有一些抵抗真菌、抵抗疟疾，甚至能够抵抗肿瘤和抵抗HIV等等的生物活性。除此之外，喹啉类化合物还在农业上、燃料上、颜料上应用广泛，是一种极其重要的杂环化合物。喹啉第一次是在煤焦油分离中发现的，后来人们用碱干馏一些抵抗疟疾的药物奎宁也得到了喹啉，现在喹啉类化合物依旧是抵抗疟疾药物的首选。因此本次研究采用全合成德尔方法合成一类喹啉类药物对抵抗疟疾、杀菌消毒有较好的疗效。89533

本论文分为以下两部分：

第一部分为文献综述部分：

该部分对喹啉、苯并咪唑、三唑和恶二唑的重要合成方法以及生理、药理活性等在国内外的研究状况作了比较系统的阐述。

第二部分为实验部分，主要工作如下：

（一）2-三唑基-3-喹啉醛的制备

（二）2-（2-三唑基喹啉-2-基）苯并咪唑的合成

（三）2-氯甲基-5-苯基-1,3,4-恶二唑的合成

（四） 2-（1H-1,2,4-三唑）-3-{2-[(1H-苯并咪唑-1-基)甲基]-5-苯基-1，3,4-恶二唑]-6-甲基喹啉的合成、分离、结构确证。

Health problems have been the most concerned about the issue, how to resist the disease has become a more popular topic and research direction, but also can well encourage the development of medical drugs。 In the field of medical drugs, many are the use of chemical synthesis means to create new drug products。 Different heterocyclic compounds have different biological activities, of which quinoline compounds are common and the effect on the drug is very obvious。 Quinoline is a more important heterocyclic ring, its substituents in a certain location will have a characteristic of the activity。 For example, quinoline substituted in the second place has some biological activity against fungi, malaria resistance, and even resistance to cancer and resistance to HIV。 In addition, quinoline compounds are widely used in agriculture, fuels, and pigments, and are an extremely important heterocyclic compound。 Quinoline was first discovered in the separation of coal tar, and later quinoline, a quinoline-resistant drug, was also the first choice for malaria drugs。 Therefore, this study using synthetic synthetic method of synthesis of a class of quinoline drugs against malaria, disinfection has a better effect。 

This paper is pided into the following two parts:

The first part is the literature review section:

In this part, the important synthesis methods of quinoline, benzimidazole, triazole and oxadiazole, as well as physiological and pharmacological activities, are described systematically at home and abroad。

The second part is the experimental part, the main work is as follows:

(A) Preparation of 2-triazolyl-3-quinolinol,

(B) Synthesis of 2- (2-triazolylquinolin-2-yl) benzimidazole

(C) Synthesis of 2-chloromethyl-5-phenyl = 1,3,4-oxadiazole

(D) The title compound 2- (1H-1,2,4-triazole) -3- {2 - [(1H-benzimidazol-1-yl] methyl] -5-phenyl- Synthesis, Separation and Structure Confirmation of 6 - Methylquinoline。

毕业论文关键词：喹啉； 1,3,4-恶二唑； 苯并咪唑；三唑

Keyword: quinoline； Oxadiazole； Benzimidazole；Triazole

目录

摘    要 3

目录 5