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摘要：由于顺磁性高分子微球有着非常突出的环保性能以及可控制性，从而近年来受到了人们高度的重视。在这些顺磁性高分子微球中，磁性壳聚糖微球具有较高代表性，它的环境友好、无毒，可生物降解等一系列的特点，已广泛的应用于医药等其他很多的领域。在数量众多的试验及研究中，经常将壳聚糖制备成微球，作为载体，该药物被用作缓释药物的载体。它需要有一个更小的粒子大小。通常为纳米级别。41069
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阿胶的应用历史可以追溯到超过两千年，与人参、冬虫夏草、鹿茸一起被称为“四宝”。阿胶道甘，性质平，无毒性，入肝、肾、肺。它有滋补和药用两个用途，具有滋阴养血，润燥止血的功能。补血效果明显，可以治疗各种疾病所致的血虚症。
本文主要研究壳聚糖-纳米磁性粒子的制备、靶向阿胶的制备、壳聚糖-纳米磁性粒子的红外表征分析，以及配比等内容。
通过实验得到的反应条件为：壳聚糖与纳米Fe3O4质量比为0.4，反应所需的反应的时间为60分钟，控制的最好的反应温度为50℃，在此条件下的最大收率为62.67%。
毕业论文关键词：壳聚糖；纳米微球；阿胶；制备
Preparation of nanoparticles of Chitosan and its targeting of donkey-hide gelatin refining
Abstract：Because of superparamagnetic polymer microspheres with outstanding environmental performance and controllability, which in recent years has been received hurge attentions from people all over the world. In these superparamagnetic polymer microspheres, representative of magnetic Chitosan microspheres and its environmental protection, toxic, readily biodegradable and other features have been widely used in many fields such as medicine. In a large number of tests and studies, Chitosans are often be prepared as microspheres, in this carrier coated medicine, the delivery system of this sustained-release drug, which has a smaller diameter, usually has micro-nano level.
Donkey-hide gelatin now has over than 2000 years of Chinese history, together with ginseng, deer horn and aweto known as the "four treasures of traditional Chinese medicine". Donkey-hide gelatin sweet, flat, and run drug, into the liver, kidneys and lungs. Medicinal tonic liangyi, with nourishing yin and supplementing blood, moistening Hemostatic function. Blood effective, good at treating various disorders caused by deficiency.
This paper studies of Chitosan nanoparticles preparation, target of the donkey-hide gelatin preparation and characterization of Chitosan nanoparticles and the best ratio of content.
The best reaction condition of this experiment is: mass ratio between Chitosan and Nano Fe3O4 is 0.4, the reaction time needs to be control at 60 minutes, the best temperature should be 50℃. Under these conditions, the maximum yield is 62.67%.
Key words: Chitosan; nanoparticles; ejiao; preparation
目录
1.前言 1
1.1纳米材料概述 1
1.1.1纳米磁性粒子的概述 1
1.1.2 磁性氧化铁纳米粒子的制备 2
1.1.3 磁性纳米粒子的表面修饰 4
1.2壳聚糖 6
1.2.1壳聚糖的概述 6
1.2.3磁性壳聚糖微球的应用 7
1.2.4磁性壳聚糖微球的制备 8
1.3靶向阿胶 10
1.3.1阿胶的概述 10
1.3.2阿胶的药理作用 10
1.3.3靶向制剂的定义与分类 11
1.3.4靶向制剂的特点 11
1.3.5中药靶向给药的研究进展 11
1.3.6靶向制剂的展望 12
2.实验方案及设备 13
2.1设计方案及创新点 13
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