摘要目的:优选止咳平喘巴布剂的基质配比，确定适合于止咳平喘巴布剂的最佳配比；测定优选的止咳平喘巴布剂中细辛脂素离体大鼠透皮率。方法:以初粘力和综合感官评价的综合评分为考察指标，采用L18（37）正交试验优化止咳平喘巴布剂的最佳基质配比；采用RYJ-6B型体外智能透皮实验仪，以离体大鼠的背部皮肤作为屏障、生理盐水为接收液，以优选的止咳平喘巴布剂中细辛脂素的累积透皮渗透量为指标，用HPLC定量检测透皮的细辛脂素含量，考察优选的止咳平喘巴布剂2、4、6、8、12、24 h时的透皮量，计算其累计透皮率。结果:止咳平喘巴布剂基质处方最佳配比为：羧甲基纤维素钠：明胶；聚丙烯酸钠：高岭土：甘油：水：氮酮+丙二醇=2。25：1。75：4。0：2。0：10。0：65：0。4；优选的止咳平喘巴布剂24 h离体透皮率为31。01%。细辛脂素的透皮扩散方程（Higuchi方程）为Q = 1。2489t1/2 + 0。7413(R² = 0。9964)。结论：按正交实验优选出的基质配方制备的止咳平喘巴布剂粘度适宜、皮肤追随性良好，剥离无膏药残留，表面平整、色泽均匀、保湿性良好；优选的止咳平喘巴布剂通过体外透皮实验证实其具有良好的缓释作用和透皮性能。89030

Abstract Objective: The optimal formulation of cough and asthma should be used to determine the optimal molding process suitable for cough and asthma Cappuccino; To determine the transdermal rate of Cappuccino in rats。 Methods: The optimal matrix ratio of cough and asthma Cappuccino was optimized by L18 (37) orthogonal test with the comprehensive score of initial viscous and comprehensive sensory evaluation; The RYJ-6B in vitro intelligent transdermal transcut Body skin as a barrier, saline as the receiving liquid to cough and asthma in the accumulation of the Asarum in the cumulative permeability of transdermal as an indicator, quantitative determination of transdermal Asarum content, 2h, 4h, 6h, 8h, 12h, 24h, and calculate the cumulative transdermal rate。 Result: The best proportion of prescription for cough and asthma should be: sodium carboxymethyl cellulose: sodium acetate: kaolin: glycerol: water: Azone + propylene glycol = 2。25: 1。75: 4。0: 2。0: 10。0: 65 : 0。4; The preferred cough and asthma Cappuccino Pakistani agent 24 h in vitro transdermal rate of 31。01% 。 The transdermal diffusion equation (Higuchi equation) of Asarum is Q = 1。2489t1/2 + 0。7413 (R² = 0。9964)。 In conclusion: According to the orthogonal experiment prepared by the matrix preparation of cough and asthma Cappuccino prescription appropriate viscosity, good skin follow-ability, stripping no plaster residue, the surface smooth, uniform color, good moisture retention; The preferred cough and asthma Cappuccino have good release and transdermal properties。

毕业论文关键词：巴布剂;正交试验;体外释放;高效液相色谱法

Keyword: Cappuccino；Orthogonal test；In vitro release；High performance liquid chromatography 

目录

1 引言 5

2 仪器与材料 6

2。1 仪器与设备 6

2。2 药材与试剂 6

2。2。1 药材与动物 6

2。2。2 试剂 6

3 方法与步骤 7

3。1 巴布剂基质配方正交试验设计 7

3。1。1