In the production process,material accounting and thermal accounting, equipment modeling and the main size to determine the completion of the workshop after the plant can start the layout of the design work. The main task of the layout of the plant is to arrange the facilities, such as the flat structure of the plant, the internal composition, the production equipment, the electrical setting of the instrument, and so on. It is designed to meet the requirements of the production process and is economical and practical. Plant layout is reasonable or not significant, it will directly affect the investment in construction projects, put into operation after operation, maintenance and safety, as well as the completion of the economic indicators. Therefore, the requirements of the technical staff to master the overall situation, overall consideration, and other relevant personnel to do a good job shop layout design.

Key words: 3 - indole butyric acid；phase transfer catalysis；process route；synthesis method

目录

1绪论

1.1 产品简介及意义

1.2 3-吲哚丁酸的历史

1.2.1 3-吲哚丁酸的研究历史

1.3 3-吲哚丁酸的合成方法

1.3.1 3-吲哚丁酸的合成方法

1.3.2 结论

2合成3-吲哚丁酸的基本原理及生产工艺流程

2.1 合成3-吲哚丁酸的基本原理

2.2 本设计的生产工艺流程

2.3 生产方法与主要工艺流程

3主要原材料的理化性质

4物料衡算

4.1 计算基准和相关数据

4.2 3-吲哚丁酸工艺设计

5工艺设备选型

5.1 设备选型依据

5.1.1 设备选型依据和原则

5.1.2 计算依据

5.2 反应釜选型计算

5.3 选型结果

5.4 过滤设备

5.4.1 化学药液过滤机产品特点

5.5 过滤洗涤干燥一体机选型

5.5.1选型依据

5.5.2选型结果

5.6 冷凝器选型

6车间布置设计

6.1 车间布置设计依据

6.2 车间布置设计的目的

6.2.1 设备与设备、建筑物间的安全距离

6.2.2车间不同操作间洁净度的设计

6.3 车间布置

6.3.1 车间布置概况

6.3.2车间布置说明

6.4 厂址选择的基本要求

6.4.1 厂址选择要求

6.4.2 《医药工业洁净厂房设计规范》

7 GMP认证与验证