介孔二氧化硅表面的炔基修饰

摘要在对HIV/AIDS、肥胖和癌症的临床治疗中联合药物治疗方案已成为一种优势策略。实现多种药物的缓释，构建二元载药体系是一大研究热点。介孔二氧化硅结合环糊精可构建二元装载体系实现多种药物的同时装载和可控释放。为将环糊精连接到二氧化硅材料上，实现二氧化硅表面的改性是首要克服的难点。本课题制备出了三种炔基修饰的二氧化硅材料，为构建二氧化硅-环糊精二元载药体系奠定基础。主要研究内容如下：1，使用多种方法制备不同链长的炔基化硅烷偶联剂；2，采用高温合成法制备炔基修饰的二氧化硅材料；3，采用高温法合成制备简易二氧化硅-环糊精载药体系，结果表明其载药率达9.13%（w/w）、药物释放率达6.94%（w/w），进一步说明二氧化硅炔基化程度符合要求。33620
毕业论文关键词二氧化硅 MCM-41 炔基药物载体
毕业设计说明书外文摘要
Title   Surface Modification of Mesoporous Silica by Alkynyl
Abstract
Combination drug therapy has become one of the dominant strategies in the clinical treatment of HIV/AIDS, diabetes, and cancer. The designation of an on-command dual-cargo release system is a hot research topic, which can realize the sustained release of two kinds of drugs. Construction of silica-cyclodextrin system meets the demand. Fabrication of alkynyl modified silica is one of the crucial issues to have cyclodextrin attached. Here, three types of alkynyl modified silica is fabricated to give the foundation of the construction of silica-cyclodextrin dual-cargo release system. The main contents are as follows: 1, Preparation of alkynyl modified silane coupling agents with different chain length in variety methods or conditions; 2, Preparation of alkynyl modified silica by high temperature synthesis; 3, Construction of silica-cyclodextrin release system. The results indicate that the drug loading rate of the system reaches 9.13% (w/w)， and the release rate 6.94% (w/w), which illuminating the successful modification of silica by alkynyl.
Keywords silica MCM-41 alkynyl drug delivery
目   次
1 绪论   1
1.1 载药体系   1
1.2 二氧化硅的炔基修饰   3
1.3 课题研究背景、研究思路、主要研究内容   4
2 硅烷偶联剂的炔基修饰   7
2.1 化学试剂与实验仪器   7
2.2 制备炔基化的硅烷偶联剂   9
2.3 结果与讨论   11
2.4 本章小结   16
3 介孔二氧化硅的炔基化及二氧化硅-环糊精体系的制备   17
3.1 化学试剂与实验仪器   17
3.2 制备炔基修饰的MCM-41   18
3.3 制备介孔二氧化硅-环糊精载药体系   19
3.4 结果与讨论   20
3.5 本章小结   25
4 载药体系药物释放性能的研究   27
4.1 化学试剂与实验仪器   27
4.2 药物装载   28
4.3 药物释放性能研究   28
4.4 本章小结   33
5 展望   34
结论   35
致谢   36
参考文献37
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缩略词   英文名   中文名介孔二氧化硅表面的炔基修饰:http://www.youerw.com/yixue/lunwen_30803.html