摘要：本课题通过单因素实验研究了包覆氧化锌的固体脂质微粒乳化体系的配方结构及制备工艺对体系的影响，优化了配方组成及制备条件，表征了固体脂质微粒的形貌特征、粒径及分散系数，同时又分析了其紫外吸收特性及储存稳定性。实验结果表明，在乳化温度为85℃，脂质原料与乳化剂用量比为1：1，氧化锌用量为脂质原料1/2条件下制得的固体脂质微粒平均粒径为300nm，粒子为圆形，分布均一，且具备良好的紫外吸收及储存稳定性。结论这种包覆氧化锌固体脂质微粒的运载系可以应用在无机防晒化妆品中，作为一种新型运载系统的防晒产品可以有效避免普通无机防晒化妆品在使用过程中的涂白效果，避免了防晒产品使用时影响美观的弊端，在使用性良好的情况下不影响其稳定性及防晒性。19852
关键词：氧化锌；单因素；固体脂质微粒；无机防晒剂；紫外吸收
Preparation and characterization of solid lipid nanoparticles loaded zinc oxide
Abstract： This paper by means of single factor experiment to research the emulsion system of ZnO solid lipid nanoparticles , through study the formula structure and preparation process of the emulsion system, optimize the preparation conditions, and represent of the morphology characteristics , particle size and dispersion coefficient of the solid lipid nanoparticles, and analyzes its ultraviolet absorption characteristics and stability. Results showed that the emulsification temperature is 80 ℃, lipid 1:1 ratio of raw materials and dosage of emulsifier, dosage of zinc oxide as the lipid material under the condition of 1/2 of solid lipid particles, the average particle size is 300 nm, particle is circular and uniform distribution, and have good ultraviolet absorption and storage stability.Conclusion the solid lipid nanoparticles carried zinc oxide was used as a transport system in the application of inorganic sunscreen cosmetics, this new type of delivery systems is prevented bask in a product can effectively avoid the common inorganic sunscreen cosmetics painted white effect in the use process, avoid the affect beautiful when using the sunscreen products. In the case of usability is good without affecting its stability and the UVA and UVB protection properties.
KeyWords： zinc oxide；single factor experiment；solid lipid nanoparticles；Inorganic sunscreen；Emulsification system；partical size
目 录
1绪论 1
1.1本课题国内外研究现状概况 1
1.2固体脂质微粒在化妆品中的应用 2
1.3防晒化妆品现状以及应用 3
1.4包覆ZnO固体脂质微粒在防晒化妆品中的应用 5
1.5本课题的研究目的和意义 6
2实验部分 7
2.1实验原料及仪器 7
2.1.1实验原料 7
2.1.2仪器设备 7
2.2样品的制备 8
2.3固体纳米脂质微粒的表征 8
2.3.1固体脂质微粒的粒径大小及分测定 8
2.3.2固体脂质微粒的显微镜观察 9
2.3.3固体脂质微粒的扫描电镜观察 9
2.3.4固体脂质微粒的稳定性测定 9
2.3.5紫外吸光度法测定样品的防晒性 9
3实验结果与讨论 11
3.1单因素优化工艺条件对体系的影响 11
3.1.1均质时间对脂质微粒粒径大小及分布的影响 11
3.1.2均质功率对脂质微粒粒径大小及分布的影响 12
3.1.3乳化温度对脂质微粒粒径大小及分布的影响 13 包覆ZnO固体脂质微粒的制备及其性能表征:http://www.youerw.com/huaxue/lunwen_11393.html