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摘要：壳聚糖是天然生物聚合物，安全无毒有生物可降解性和生物相容性。当引入羧甲基时，可以大大增加壳聚糖在中性和碱性溶液PH条件下的溶解性而并不影响他们的自身的特点。本论文利用羧甲基壳聚糖以及优尔种保湿剂制备成膏霜，对其制备条件进行优化。测定羧甲基壳聚糖羧化度，单体保湿剂的体外称重法以及保湿霜的载体保湿评价来比对不同保湿剂的保湿性能和吸湿性能，并分析其优缺点。实验结果表明，羧甲基壳聚糖具有水溶性，矿物油脂和天然油脂的用量和复配程度以及不同保湿剂的性态对保湿霜的状态和浓稠度有较大影响，保湿剂的保湿效果与分子量相关。最后，改性的壳聚糖有了可应用的原料来源和市场实用的需要，成为一个水溶性，保湿性，生物相容性好的且低毒性安全的化妆品原料，羧甲基壳聚糖是一种应用前景很好的保湿剂，可以在保湿性功效化妆品中使用。5955
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关键词：羧甲基壳聚糖；保湿霜；保湿性能；吸湿性能
Preparation and moisturizing properties evaluation of moisturizer cream containing of carboxymethyl chitosan
Abstract: Chitosan are natural biopolymers that are non-toxic, biodegradable and biocompatible. Introducing small chemical groups to Chitosan structure, such as carboxymethyl groups, can drastically increase the solubility of chitosan at neutral and alkaline pH values without affecting their characteristics. In this paper, which optimizes the preparation conditions of the moisturizer cream containing carboxymethyl chitosan and the other six moisturizers. Determine the carboxylation degree of the raw material carboxymethyl chitosan and the moisturizing properties of the moisturizer cream including monomer moisturizer inside and outside the body. The results show that not only the dosage and the match degree of mineral oil and the natural oil but also the different kind of the moisturizer have at great impact on the state and the dense of the cream. The moisturizing effect is related to molecular weight and the external condition, different species of ingredients have a great effect on the moisturizers and moisturizing properties. Carboxymethyl chitosan derivatives have wide applications in the field of cosmetics due to their high water solubility and positive anti-microbial characteristics.
Key Words : Carboxymethyl chitosan; Moisturizer; Moisturizing properties; Hygroscopic properties
目 录
1.前言 1
1.1 羧甲基壳聚糖的概述 1
1.2 羧甲基壳聚糖的形成与结构 2
1.3 羧甲基壳聚糖的制备方法 3
1.4 羧甲基壳聚糖的研究现状 3
1.5 羧甲基壳聚糖在化妆品中的应用 5
1.6 本课题的研究目的和意义 5
2. 实验内容 7
2.1 拟使用的材料试剂、仪器设备 7
2.1.1 实验材料与试剂 7
2.1.2 实验仪器与设备 9
2.2 实验方法 9
2.2.1 羧甲基壳聚糖羧化度的测定 9
2.2.2 含不同保湿剂的保湿霜的制备 10
2.2.3 含不同保湿霜的体表皮肤水分测定 12
2.2.4 体外称重法测试保湿剂的保湿性能和吸湿性能 13
2.2.5 保湿霜耐热耐寒性的测定 14
3. 结果与讨论 15
3.1 制备工艺对保湿霜稳定性、分散性和使用肤感的影响 15
3.1.1 油脂及其配比的影响 15
3.1.2 乳化剂的影响 16
3.1.3 保湿剂的影响.......17
3.2 羧甲基壳聚糖羧化度的测定结果.17
3.3不同保湿剂保湿吸湿性能大小的比较 18