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摘要：膦酸酯类化合物在有机合成、阻燃材料、医疗卫生和生物化学中发挥着极其重要的作用，应用及其的广泛，开发易操作、经济、高效、绿色合成P-S-C键化合物的有效方法是化学工作者一直以来都在不懈追求的目标。近几年关于P-C(sp2 和 sp3)键形成的反应方面的报道特别多，过渡金属钯催化、铜催化、到镍催化等等，过渡金属催化P-C键的构成已受到了深入而广泛的研究，并取得了巨大的成就。但是，传统构建P-C键的方法并不能满足合成具有更多大官能团化的有膦酸脂类化合物的要求，而且对于碳杂键(C-X)的反应研究特别少还不够全面。43163
在P-C键构建的方法中，膦酸酯类化合物的合成受到极大广泛的关注。近几年来，芳香腙作为一种安全和方便的由羰基化合物制备重氮化合物的替代化合物，用于很多新的反应中，例如X-H(X = C, N, O)的插入反应，过渡金属催化反应，环丙烷化，环氧化，氮杂环丙烷化反应等。本论文研究了不同条件下苯甲醛对甲苯磺酰腙与硫粉和二苯基氧膦构建P-S-C键形成的反应，不同条件下及在过渡金属催化时对反应的影响-优尔^文-论+文网www.youerw.com。
毕业论文关键词： 膦酸酯类化合物，P-C键，过渡金属催化，P-S-C键
Study on green synthesis of P-S-C bond compound built by the aryl hydrazone
Abstract: Phosphonate compounds play in organic synthesis, flame-retardant materials, medical biochemistry and an extremely important role in a wide range of applications and to develop and easy to operate, economical, efficient and effective method for green synthesis of chemical compounds are key PSC worker has been in the relentless pursuit of the goal. Responses reported in recent years on PC (sp2 and sp3) bond formation particularly transition metal palladium catalysis, catalytic copper, the nickel catalyst, etc., transition metal-catalyzed PC key constituent has been intensive and extensive research, and has made tremendous achievements. However, the conventional method for constructing P-C bond does not meet
synthesize more big functionalized lipid compounds have acid requirements, but also for hybrid carbon bond (C-X) reaction with particularly low not comprehensive enough.
In the process of constructing the P-C bond in the synthesis of phosphonate compounds is greatly widespread concern. , E.g. XH (X = C, N, O) of the insertion reaction, transition metal catalyzed recent years, aromatic hydrazone as a safe and convenient alternative to the compound from a carbonyl compound prepared diazo compound, for many new reaction The reaction, cyclopropanation, epoxidation, aziridination reactions. This paper studies the benzaldehyde of tosylhydrazones and elemental sulfur and diphenyl phosphine oxide under different conditions to build P-S-C bond formation reactions, under different conditions and the influence on the reaction of the transition metal catalysis.
Keywords: Phosphonate;P-C bond,;a transition metal catalyst;P-S-C bond
Abbreviations
符号 英文含义 中文含义
DIEA Ethyldiisopropylamine N,N-二异丙基乙胺
EA Ethyl acetate 乙酸乙酯
Et3N 1, 2-dimethoxyethane 三乙胺
KOtBu Potassium tert-butoxide 叔丁醇
MeCN Acetonitrile 乙腈
PE Petroleum ether 石油醚
TLC