摘要：拉西地平为片剂，临床上多用于治疗高血压。拉西地平是一种二氢吡啶类钙通道阻滞药物。效果为扩张周围动脉，降低心脏后负荷，降低周围血管阻力、降低血压。本课题的研究目的是设计拉西地平的车间工艺流程，力求建立一条严谨、高效、有序的生产线，以三苯基膦、氯丁酸叔丁酯等产品为原料，经过季磷化工序、中和工序、缩合工序、环合工序四步工序得到拉西地平粗品，再经过精制得到拉西地平成品，本文对整个过程进行了详细的阐述与设计，最终给出设计说明书。本设计的主要内容为物料衡算、能量横算、工艺设备选型、公用工程主管的管径计算、车间布置等，绘制了工艺管道及仪表流程图（PID）、工艺设备平面图、车间主管平面布置图等。70714

毕业论文关键词：拉西地平；物料衡算；管道仪表工艺流程图；车间平面布置图

Process design of an annual output of 30 tons of  Lacidipine

Abstract: Lacidipine is a tablet that can be used in the treatment of hypertension. This product is two dihydropyridine calcium channel blocker. The effect is to dilate the peripheral arteries, reduce afterload, decrease peripheral vascular resistance and lower blood pressure. The purpose of this research is the workshop process design of lacidipine, strive to establish a rigorous, efficient and orderly production line, with three phenyl phosphine chloride, butyric acid tert butyl ester products such as raw materials, through the Quaternary sequence, phosphorus chemical neutralization procedure, condensation process, cyclization step four step by lacidipine crude product. After the refined lacidipine product, this paper expounds and detailed design of the whole process, finally gives the design specification. The main content of this design is the material balance, energy calculation, equipment selection, cross process utilities charge diameter calculation, workshop layout, drawing the process piping and instrument diagram (PID) technology, equipment layout, workshop supervisor layout etc..

Key Words: Lacidipine；Material balance;Piping and instrument process flow sheet; work loor plan

目录

1前言 1

1.1 设计的目的及意义 1

1.2设计依据及基础资料 1

1.3产品名称和设计规模 1

1.4产品描述 1

1.4.1简介 1

1.4.2市场情况 2

1.5 主要原辅材料物性参数 2

2.工艺说明 5

2.1工艺路线 5

2.2工艺流程框图 6

2.3 工艺流程叙述 7

3.生产制度 10

3.1生产计划 10

3.2 生产安排原则 10

3.3生产班制 10

4.物料衡算 11

4.1计算基准和相关数据 11

4.2物料衡算 11

5 能量衡算 20

5.1 能量衡算目的 20

5.2拉西地平能量衡算 20

5.2.1各种参与过程的物质的比热 20