总之，化工设计对新厂（车间或装置）建设，老厂改造挖潜，小试或中试装置建立都具有极其重要的作用。也可以说，设计是生产的前导，是科研成果转化为工业化大生产的必经途径。

1。 任务的来源

本设计是根据对醋氯芬酸的科研小试报告以及相关实验数据而设计的一次工业规模化的模拟。其根本的目的是运用化学工程相关的知识及操作手段而进行的一次模拟化工设计的尝试，并且为醋氯芬酸的工业化生产、生产设备的设计提供参考。作为模拟设计，本文将会省略化工设计的部分内容，即工艺管路设计、防爆电气设计、动力设计和工厂整体布置等。

2。 设计标准

本设计参考了以下国家标准和规定[6]

a。 常用危险化学的分类标准(GB13690-1992)

b。 生产过程中危险品和有害因素的分类与代码(GB/T13816-1992)

c。 压力容器中化学介质典型危害和爆炸危险程度的分类(HGJ43-1991)

d。 钢制压力容器(GB150)

e。 管壳式换热器标准(GB151)

f。 工厂防火规定(GBJ16-1987)

g。 污水综合排放规定(GBJ8978)

h。 工艺系统设备布置设计规定(HG20570)

i。 化工装置管道布置设计规定(HG/T20549)

3。 设计原则及主要设计指标

原则：(1) 安全：化工生产中产生的大量化合物是易燃、易爆或者有毒性的。因此，设计必须充分考虑各种明显的和潜在的危险，保证生产人员的健康和安全。

(2) 操作方便：在确定各个生产过程及设备的同时，还要确定合理的操作条件。因为它对生产过程和设备的确立以及其作用的发挥和控制方案的确定有着直接的关系。

(3) 投资省：即要求经济地投资使用设备、土建投资、公用工程的投资和人力成本。

(4) 便于安装：工厂布置必须满足施工以及安装作业的要求。特别是应该考虑大型设备的吊装，厂内道路的路面结构和载荷标准等都应满足施工安装的要求。

关键词：醋氯芬酸；双氯芬酸；设计；反应釜

Instruction manual:

Design Project: An annual 50 tons for Aceclofenac process design。

Aceclofenac, chemically known as 2- (2,6-dichloroanilino) phenylacetoxyacetic acid is a nonsteroidal antiinflammatory drug developed by Almirall-Prodesfarma Pharmaceuticals in Spain, a prescription for diclofenac, and Aceclofenac also is a prodrug of diclofenac。 In 1992 Aceclofenac was first listed in Spain, then this drug came into the market in Portugal, Germany, Britain and other countries。 And In 1998 Aceclofenac was also collected in the European and British Pharmacopoeia。 This product is a new synthetic oral non-steroidal drugs, but is also a phenylacetic acid drugs that can be anti-inflammatory, antipyretic and analgesic, The drug has the small untoward effect on the gastrointestinal tract ,and also having the good tolerance。 In the structure, aceclofenac is associated with diclofenac, aphaclofenac and fencofen acid。 In clinical practice, compared with other nonsteroidal drugs (NSAIDs), it is characterized by a wide range of antiinflammatory, potent and antipyretic effects and gastric toxicity in acute and chronic inflammatory models。 It has a wide range of antiinflammatory effects, potent analgesic and antipyretic and gastric toxicity in acute and chronic inflammatory experimental models。 So aceclofenac is useful for treating a variety of rheumatoid arthritis, also applies to a variety of diseases caused by pain and fever, and is the treatment of acute and chronic pain, anti-inflammatory safe and reliable drugs。 

At present, non-steroidal drugs are the most commonly used analgesic drugs in clinical practice。 COX-2 predisposing inhibitors and COX-2 specific inhibitors in non-steroidal drugs have been widely used in clinical, because the pain is closely related to cyclooxygenase 2 (COX2)。 However, In 2003 the US found that using COX-2 specific inhibitors for a long time will increase the incidence of cardiovascular events, so in recent years aceclofenac as a representative of the COX-2 predisposing inhibitors has been widely used in clinical。