摘要近些年来,由于微流控芯片在系统自动化、集成化、便携化和高效化等方面的巨大潜力,它已经成为分析仪器发展的重要方向。在流体学中,为了实现对微尺度下流体的精确操控, 提出一种基于介质上电润湿的新型微液滴驱动芯片,而在液滴的操作过程中,液滴的配发往往是非常关键的第一步操作。本论文在进一步分析Lippaman-Young方程和液滴内部压力的基础上建立了介质上电润湿配发的理论模型,得到液滴成功配发两个步骤的理论条件,即液柱形成条件和液滴夹断条件。在此基础上,进行了液滴配发操作芯片的设计和制备,并且成功进行了片上液滴配发实验。通过实验,本论文着重分析了影响液滴操作的可配发性和可重复性的重要因素,为更好的进行片上液滴配发操作奠定了理论和实验基础。20983
关键词 微流控芯片 液滴配发 介质上电润湿 可重复性 毕业论文设计说明书(论文)外文摘要
Title On-chip Droplet dispensing using electrowetting-based liquid actuator
Abstract
In recent years, due to their great potential in the system automation, integration, portability and high efficiency, etc., microfluidic chips has become an important direction for the development of analytical instruments. In fluidics, in order to achieve precision control in microscale, an electrowetting-based liquid droplet actuation chip has been proposed. In many droplet actuation processes, the droplet dispensing is often the first critical step. This study presents a theoretical model for droplet dispensing on the basis of Lippaman-Young equation and droplet pressure evolution. Two theoretical conditions for successful dispensing has been demonstrated- the protrusion of liquid finger and droplet pinch-off. Accordingly, we have designed and fabricated microfluidic droplet dispensing chips, and tested their dispensing performances. Experimental analysis show important influence of actuation parameters on the droplet dispensability and dispensing repeatability. This study provides useful guidancefor better chip design and actuation parameter selection.
Keywords Microfluidic chip Droplets dispensing Electrowetting on dielectric Reproducibility
目录
1 绪论 1
1.1 本课题的背景介绍 1
1.1.1 课题名称解释 1
1.1.2 课题研究的发展历程 1
1.2国内外研究现状 3
1.2.1 液滴形成技术的研究现状 3
1.2.2 液滴操作技术的研究现状 4
1.3课题研究意义 5
1.3.1电润湿的研究意义 5
1.3.2 微流控芯片的研究意义 6
1.4 本论文研究的主要内容 7
2.1 Lippmann-Young方程与Laplace方程 9
2.1.1 表面张力 9
2.1.2 Lippmann-Young方程 9
2.1.3 接触角饱和 11
2.1.4 接触角滞后 12
2.1.5 电润湿中的电解 13
2.1.6 Laplace方程 13
2.2液柱形成的理论分析 14
2.3液滴夹断的理论分析 15
2.4结论 16
3.1芯片制备与实验方法 17
3.2片上液滴的可配发性研究 18
3.2.1 片上液滴配发的实验模型 18
3.2.2实验数据与分析 19