16。 Shimizu M, Tainaka H, Oba T, Mizuo K, Umezawa M, Takeda K。 Maternal exposure to nanoparticulate titanium dioxide during the prenatal period alters gene expression related to brain development in the mouse。 Part Fibre Toxicol, 2009, 6:20。
17。 Takeda K, Suzuki K, Ishihara A, Kubo-Irie M, Fujimoto R, Tabata M, Oshio S, Nihei Y, Ihara T, Sugamata M。 Nanoparticles Transferred from Pregnant Mice to Their Offspring Can Damage the Genital and Cranial Nerve Systems。 J Heal Sci, 2009, 55:95-102。
18。 Hougaard KS, Jackson P, Jensen KA, Sloth JJ, Loschner K, Larsen EH, Birkedal RK, Vibenholt A, Boisen AM, Wallin H, Vogel U。 Effects of prenatal exposure to surface-coated nanosized titanium dioxide (UV-Titan)。 A study in mice。 Part Fibre Toxicol, 2010, 7:16。
19。 Chen J, Dong X, Zhao J, Tang G。 In vivo acute toxicity of titanium dioxide nanoparticles to mice after intraperitioneal injection。 J Appl Toxicol, 2009, 29:330-337。
20。 Blank F, Rothen-Rutishauser B, Gehr P。 Dendritic cells and macrophages form a transepithelial network against foreign particulate antigens。 Am J Respir Cell Mol Biol, 2007, 36:669-677。
21。 World Health Organization (WHO): Environmental Health Criteria 24-Titanium。 In International Programme on Chemical Safety。 Geneva: World Health Organization, 1982。
22。 Huggins CB, Froehlich JP。 High concentration of injected titanium dioxide in abdominal lymph nodes。 J Exp Med, 1966, 124:1099-1106。
23。 Oberdrster G, Ferin J, Lehnert BE。 Correlation between particle size, in vivo particle persistence, and lung injury。 Environ Health Perspect, 1994, 102:173-179。
24。 Scherle PA, Jones EA, Favata MF, Daulerio AJ, Covington MB, Nurnberg SA, Magolda RL, Trzaskos JM。 Inhibition of MAP kinase kinase prevents cytokine and prostaglandin E2 production in lipopolysaccharide-stimulated monocytes。 J Immunol, 1998, 161:5681-5686。
25。 Das J, Choi YJ, Song H, Kim JH。 Potential toxicity of engineered nanoparticles in mammalian germ cells and developing embryos: treatment strategies and anticipated applications of nanoparticles in gene delivery。 Hum Reprod Update, 2016, 22(5):588-619。
26。 La Z, Yang WX。 Nanoparticles and spermatogenesis: how do nanoparticles affect spermatogenesis and penetrate the blood-testis barrier。 Nanomed, 2012, 7(4):579-596。
27。 Hong FS, Yu XH, Wu N, Zhang YQ。 Progress of in vivo studies on the systemic toxicities induced by titanium dioxide nanoparticles。 Toxicol Res, 2017, 6:115-133。
28。 Lu PJ, Ho IC, Lee TC。 Induction of sister chromatid exchanges and micronuclei by titanium dioxide in Chinese hamster ovary-K1 cells。 Mutat Res, 1998, 414(1-3):15-20。
29。 Suzuki H, Toyooka T, Ibuki Y。 Simple and easy method to evaluate uptake potential of nanoparticles in mammalian cells using a Flow Cytometric Light Scatter Analysis。 Environ Sci Technol, 2007, 41 (8):3018-3024。
30。 Di Virgilio AL, Reigosa M, Arnal PM, Fernández Lorenzo de Mele M。 Comparative study of the cytotoxic and genotoxic effects of titanium oxide and aluminium oxide nanoparticles in Chinese hamster ovary (CHO-K1) cells。 J Hazard Mater, 2010, 177:711-718。
31。 侯娟, 万旭英, 王飞, 许桂凤, 刘珍, 张天宝。 纳米级二氧化钛对体外大鼠腔前卵泡生长发育成熟的影响。 第二军医大学学报, 2009, 30(8):869-873。
32。 Gao GD, Ze YG, Li B, Zhao XY, Zhang T, Sheng L, Hu RP, Gui SX, Sang XZ, Sun QQ, Cheng J, Cheng Z, Wang L, Tang M, Hong FS。 Ovarian dysfunction and gene-expressed characteristics of female mice caused by long-term exposure to titanium dioxide nanoparticles。 J Hazard Mater, 2012, 243:19-27。
33。 Zhao XY, Ze YG, Gao GD, Sang XZ, Li B, Gui SX, Sheng L, Sun QQ, Chen J, Cheng Z, Hu RP, Wang L, Hong FS。 Nanosized TiO2-induced reproductive system dysfunction and its mechanism in female mice。 Plos One, 2013, 8(4):e59378。