摘要：黄芩是一种沿用已久的中国传统中草药。黄芩具有清热燥湿，凉血安胎，解毒的功效。主要用来治疗温热病、上呼吸道感染、肺热咳嗽、湿热黄胆、肺炎、痢疾、咳血、目赤、胎动不安、高血压、痈肿疖疮等症状。黄芩中含有的脂溶性成分黄芩苷具备很多的药理作用，在医学领域有很广泛的应用。但是由于黄芩苷的溶解性和渗透性较低，其口服制剂药效一直不理想。利用具有增溶性质的天然物质天然糖苷，我们进一步研究增强黄芩苷水溶性的方法。本研究将黄芩苷和增溶物质甜茶苷、70%甜茶苷、甜菊糖苷、JH-90四种物质分别溶解到无水乙醇的溶剂中，黄芩苷分子和增溶剂分子间形成水溶性胶束，从而使黄芩苷的水溶性增强。实验数据表明黄芩苷-增溶剂微米微粒能有效的增加药物的溶解度，减少药物的挥发和氧化等，并且提高其生物利用率，本文通过天然微米颗粒产物的办法，探讨了制备该包合物的最佳工艺条件，为天然糖苷在水溶性黄芩苷药剂的研制提供了依据。77557

毕业论文关键词：天然糖苷；黄芩苷；微米颗粒；溶解度；生物利用率

Application of Natural Glycosides in drug dissolution

Abstract:Scutellaria is a long-standing traditional Chinese herbal medicine。 Scutellaria has a heat dampness, cooling blood tocolysis, detoxification effect。 Mainly used to treat warm disease, upper respiratory tract infection, Hyperactivity cough, hot and humid yellow, pneumonia, dysentery, hemoptysis, red eyes, fetal movement disturbed, high blood pressure, carbuncle swollen boils and other symptoms。 Scutellaria baicalensis contains fat-soluble ingredients Baicalin has a lot of pharmacological effects in the medical field has a wide range of applications。 However, due to the low solubility of baicalin and permeability, its oral preparation efficacy has been unsatisfactory。 We have further studied the method of enhancing the water solubility of baicalin by using the natural substance natural substance with the solubilizing property。 In this study, four kinds of baicalin and solubilizing substance sweet chitin, 70% sweet stevia glycosides, stevioside and JH-90 were dissolved in the solvent of ethanol, and the water-soluble micelles were formed between baicalin and solubilizing agent。 Thereby enhancing the water solubility of baicalin。 The experimental data show that baicalin-solubilizing agent microparticles can effectively increase the solubility of drugs, reduce the volatilization and oxidation of drugs, and improve their bioavailability。 In this paper, the preparation of the clathrate by the method of natural micron particles The best technological conditions for the natural glycosides in the development of water-soluble baicalin pharmaceutical provides a basis。

Keywords:Natural glycosides; baicalin; natural micron particles; enhanced solubility; bioavailability

目  录

1 绪论 1

1。1 概述 1

1。1。1黄芩概述 1

1。1。2 黄芩苷概述 1

1。1。3甜茶苷概述 1

1。1。4甜菊糖苷概述 1

1。1。5黄芩的功效作用 2

1。1。6黄芩苷的功效作用 2

1。2 黄芩苷水溶性制剂的研究现状 3

1。2。1表面活性剂法 3

1。2。2助溶剂法 3

1。2。3改变难溶性物质的结构 4

1。2。4改变溶剂组成