摘要口腔中容易滋生各种细菌，如果牙科材料不具备良好的抗菌性能会诱发龋齿等口腔疾病，因此制备抗菌性能良好的修复材料具有十分重要的意义。本课题设计、合成了两种可聚合的不对称双子季铵盐单体：MEBU-TMHDA-C12和MEBU-TMHDA-C14，红外和核磁共振确定两种单体的分子结构。将抗菌功能组分分别以抗菌单体，抗菌预聚物及纳米抗菌微球三种不同的形式添加入通用的牙科修复树脂中。将抗菌单体直接添加到牙科修复材料中，经红外光谱表征与图谱拟合计算，混合体系的双键转化率分别为72%和64%。抗菌预聚物和纳米抗菌微球则不溶于树脂体系，因此，在牙科修复材料的研究中主要还是将抗菌单体与树脂基单体均匀混合并共聚固化制得。64299

毕业论文关键词  不对称双子季铵盐  抗菌  牙科修复材料   双键转化率

毕业设计说明书（论文）外文摘要

Title    The preparation of new dental antimicrobial repairing material and the research of microstructure                     

Abstract All kinds of bacteria are easy to breed in the oral cavity,if the dental materials do not have good antibacterial properties,it will induce dental caries and other oral diseases,so the preparation of antibacterial repairing material with good performance is very important.The purpose of this study was to design and synthesize skew symmetric gemini quaternary ammonium salt-type monomer with double bond, MEBU-TMHDA-C12 and MEBU-TMHDA-C14 and characterization of their structures.There are three different forms of antibacterial components such as,monomer,polymer and particle.Then add them in the resin matrix dental monomer.The antibacterial monomer added directly to the dental restorative materials,then the monomer is incorporated to the dental restorative resin to get antibacterial agents. The double bond conversion is calculated by and the result is 72% and 64%.Antibacterial prepolymer and anti-bacterial nano microsphere is insoluble in resin system,therefore, in the study of dental restoration materials , adding antibacterial monomer directly in the dental restorative materials is the main method.

Keywords  skew symmetric gemini quaternary ammonium salt  antibacterial    resin matrix dental monomer   double bond 

1 引言 1

1.1  常见抗菌剂/抗菌材料及其抗菌机理 2

1.1.1  无机抗菌剂及其抗菌机理 2

1.1.2  有机抗菌剂及其抗菌机理 3

1.1.3天然抗菌剂及其抗菌机理 8

1.2  季铵盐抗菌剂的研究进展 9

1.2.1  单链季铵盐杀菌剂的发展和抗菌机理 9

1.2.2  双链季铵盐杀菌剂的发展和抗菌机理 9

1.2.3  双子季铵盐杀菌剂的发展和抗菌机理 10

1.2.4  聚合季铵盐杀菌剂的发展和抗菌机理 11

1.2.5  混合季铵盐杀菌剂的发展和抗菌机理 11

1.2.6  季铵盐抗菌剂的研究展望 12

1.3  本课题要研究或解决的问题 13

2  两种可聚合抗菌单体的合成与表征 13

2.1  引言 13

2.2  两种可聚合单体的合成