摘 要 芳醚类化合物是一类重要的含氧化合物,它们广泛存在于许多具有生理、药理活性的天然产物或药物分子中。因此，通过碳氧键的形成来构建芳醚类化合物一直受到有机合成化学家们的高度关注。其中，二芳基醚类化合物在聚合物、生命科学、农药、医药、卫生等领域均具有重要的应用,如对硝基二苯醚类化合物是合成局部麻醉剂、杀真菌剂、杀细菌剂，以及聚酰亚胺封端剂合成的重要中间体化合物。本文以间二苯酚为原料，经过碘取代生成2-碘代间苯二酚，然后亲电取代生成2,6-二（4-对甲苯磺酰氧基）碘苯，接着合成2-碘-3-（4-对甲苯磺酰氧基）苯酚，然后合成1-碘-2 -（2-硝基苯氧基）-6-（4-对甲苯磺酰氧基）芳基醚。之后，进一步合成 1-碘-2 -（2-氨基苯氧基）-6-（4-对甲苯磺酰氧基）芳基醚。最后，合成反应终产物1-碘-2 -（2-碘代苯氧基）-6-（4-对甲苯磺酰氧基）芳基醚。这一过程中，每一步反应产物都薄层色谱法观察反应进度，最后用柱层析法提纯。之后，产物用核磁和红外的方法来对其的结构进行表征，进而解谱。该合成方法反应条件温和，选择性较高。89548
Abstract Aromatic ether derivatives are a serious of important compounds, which are widely present in many natural products or drug molecules with physiological and pharmacological activities。 Therefore, the synthesis of aromatic ether by the formation of carbon and oxygen bonds has been highly concerned by organic chemists。 The aromatic ethers have important applications in polymers, life science, pesticide, medicine, health and other fields, such as the two nitro diphenyl ether compounds are synthetic local anesthetics, fungicide, bactericide, and polyimide terminated intermediate agent synthetic compounds。 In this paper, two phenol as raw material, after the formation of 2- iodine iodine substituted resorcinol, and electrophilic substitution of 2,6- two generation (4- tosyloxy) iodobenzene, then the synthesis of 2- -3- iodine (4- tosyloxy) phenol, and synthesis of 1- iodine -2 - (2- phenoxy) -6- (4- tosyloxy) aryl ether。 After that, further synthesis of 1- iodine - -2 (2- amino phenoxy) -6- (4-) - aryl ether。 Finally, the synthesis of the final product of 1- iodine -2 - (2- iodine phenoxy) -6- (4-) of aryl ether。In this process, every step of the reaction products were observed by thin-layer chromatography, and finally purified by column chromatography。 After that, the products were characterized by NMR and IR, and then the spectra were resolved。The method has mild reaction condition and high selectivity。
毕业论文关键词：二芳基醚； 合成； 表征； 芳基醚类化合物； 多官能
Keyword: Aromatic ether； Synthesis； Characterization； Aryl ether compounds； Polyfunctional
目录
摘 要 4
1引言 5
1。1二芳醚的源Q于W优E尔A论S文R网wwW.yOueRw.com 原文+QQ75201,8766 应用 5
1。1。1医药方面的用途 5
1。1。2农业方面的用途 5
1。1。3工业方面的用途 5
1。2二芳醚的合成 5
2正文 6
3结果与展望 6
3。1实验结果与讨论 6
3。2二芳醚类化合物的展望 6
4实验部分 6
4。1 2-碘代间苯二酚的合成 6
4。2 2,6-二（4-对甲苯磺酰氧基）碘苯的合成 多官能化芳基醚的合成及应用:http://www.youerw.com/yixue/lunwen_191789.html