摘要金属材料的研究在生物材料领域十分活跃，其中钛合金在医疗器械制造中有着广泛的应用，其良好的生物相容性让它成为骨骼植入材料及牙科植入材料的首选。为改善钛与骨组织之间的结合性，表面一般覆盖与人体组织相近的羟基磷灰石（HAP）涂层。HAP化学稳定性好，在人体内降解速度很慢，但不具备成骨诱导性，与之对应的是，透钙磷石（DCPD）具有良好的溶解性，其在体内环境中释放出的Ca2+、PO43-离子可刺激干细胞的成骨分化，有效的促进骨骼的再生长。目前DCPD涂层主要通过化学、电化学沉积法制备，涂层中往往含有其他钙磷化合物，而且往往制备周期较长。86798

本实验尝试通过滴加法，浸泡法，喷雾法这三种工艺，通过物理析出的方法在纯钛表面形成一层DCPD涂层。使用扫描电子显微镜(SEM)和X射线衍射仪(XRD)对形成的涂层进行表征测试与分析。研究三种工艺对DCPD沉积与生长的影响。其中滴加法沉积的DCPD以团簇的球化生长为主，不利于平铺成膜；浸泡法的工艺下DCPD呈针片状，在有限个形核点内重复形核生长，也不能形成完整的涂层；在喷雾法工艺下试样表面形成了完整的DCPD涂层，且涂层细度随喷雾次数的增加而增加，有向毛绒状发展的趋势，效果良好。

毕业论文关键词：钛；生物材料；钙磷涂层；表面处理

Abstract  Researches on metallic materials are very active in biological field。 Among them, titanium and its alloys are widely used in the manufacture of implantable medical devices, due to good biological compatibility and have become the first choice for skeletal implants and dental implant materials。 In order to improve the bonding between titanium and bone tissue, a hydroxyapatite (HAP) coating which is chemically similar to human bone tissue is generally fabricated on titanium surface。 HAP is of good chemical stability in vitro and therefore is not osteoinductive。 In contrast, brushite (DCPD) is of good solubility and the in vivo release of Ca2+ and PO43- ions can stimulate osteogenic differentiation of stem cell and effectively promote the bone regeneration。 At present, DCPD coating is mainly prepared by chemical and electrochemical deposition, which often contains other calcium and phosphorus compounds, and is usually time consuming。

  In this experiment, we try to prepare a layer of DCPD coating on the surface of pure titanium by physical precipitation method through the three processes of drop addition, soaking and spraying。 The formation of the coating was characterized by scanning electron microscopy (SEM) and X - ray diffraction (XRD)。 The effects of three kinds of processes on the deposition and growth of DCPD were evaluated。 The drop addition method induced a DCPD clusters of ball shape on substrate, whereas, DCPD by soaking process is needle flake shape and grew in limited nucleation sites, which could form a integrate coating。 Spraying technology fabricated a complete DCPD coating on titanium surface and coating fineness increased with increase of the number of spray, showing plush like micromorphology。

Keywords: Titanium; biological materials; calcium phosphate coating; surface treatment

目   录

第一章 绪论··1

1。1 生物材料··1

1。2 金属生物材料·2

1。3 钛及其合金在医疗器械的应用·4

1。4 新型生物用钛合金的研究与开发·5

  1。4。1 α+β型钛合金·6

  1。4。2 β型钛合金··6

  1。4。3 其他钛合金·7

1。5 钛合金的表面改性··7

  1。5。1 骨形成促进处理9

1。5。2 机能性高分子固化··10