摘要聚酰胺-胺( PAMAM)类树状分子是一类高度支化、具有特定三维结构、分子尺寸和构型高度可控的树枝状大分子，其独特的分子结构与物理化学性质使之在众多领域有着广泛的应用前景，并迅速发展为研究热点之一。将PAMAM类化合物在生物医学与自组装模板两大重要领域的研究进展及成果进行了归纳与总结,同时对此类大分子未来的研究方向作以展望。

采用发散合成法合成了以乙二胺为核的1.0～2.5代的系列树枝状高分子聚酰胺一胺(PAMAM)。采用IR、核磁共振、端基分析对PAMAM的结构进行了表征，考察了PAMAM水溶液的表面活性及其对难溶药物水杨酸的增溶能力。结果表明：半代PAMAM具有一定的表面活性，整代PAMAM几乎没有表面活性，表面活性主要与PAMAM的端基结构有关；PAMAM对难溶药物水杨酸具有增溶作用，增溶能力随代数和质量浓度的增加而增大，增溶方式与传统的表面活性剂不同。64163

毕业论文关键词  树枝状大分子  聚酰胺-胺  生物医学  自组装模板  合成  表面张力  增溶

毕业设计说明书（论文）外文摘要

Title  The synthesis and characterization of dendrimer of the polyamide - amine

Abstract Polyamide - amine class dendrimer (PAMAM) dendrimers are a class of highly branched, with a specific three-dimensional structure, molecular size and configuration of highly controllable, its unique molecular structure and physicochemical properties of so manythe field has a broad application prospects, and quickly developed into one of the focus. PAMAM compounds in biomedical research progress and results of two major areas of self-assembly template and summarized on of such macromolecules future research direction for Looking.

Divergent synthesis method ethylenediamine core generation series of 1.0 to 2.5 dendrimer polyamide amine (PAMAM). By IR, NMR end group analysis were used to characterize the structure of PAMAM investigated PAMAM aqueous solution of surfactant and its solubilization of poorly soluble drugs salicylic acid. The results show that: half generation PAMAM having a certain surface activity the whole generation PAMAM almost no surfactant, a surfactant with the end group structure of the PAMAM; PAMAM solubilization of poorly soluble drugs salicylate, solubilization capacity with the Generation and the mass concentration increases, solubilization with a conventional surface active agent type.

Keywords  the dendrimer  polyamide-mine  biomedical  self-assembly template   synthesis  surface tension  solubilization

1  引言 1

1．1  结构和性质 2

1.1.1  结构 2

1.1.2  结构特点 2

1.1.3  性质 3

1．2  合成方法 3

1.2.1  发散法(Dive rgentMethod) 3

1.2.2  收敛法(ConvergentMe thod) 4

1.2.3   发散收敛共用法(Dive rgent -ConvergentMethod) 4

1．3  表征 4

1．4  应用 5

1.4.1  催化剂 5

1.4.2  金属纳米材料 5

1.4.3  纳米复合材料 6

1.4.4  膜材料 6

1.4.5  表面活性剂 6

1.4.6  生物医药领域