摘要：开环易位聚合（ROMP）反应是现阶段来说被广泛使用来合成功能化聚合物的一个方法，在近二十年多年来众多科学家都在对此进行探索。Grubbs等所研发得到的Grubbs催化剂常常被用作于ROMP反应的催化剂，主要还是因为它的热稳定性相当不错和官能团耐受性也比较强，获取得产物结构也较为清晰明确，而且对于环张力较大的降冰片烯（NBE）类单体来说它作为催化剂具备着相对比较优异的反应活性。同时葡萄糖是一种具有旋光异构体，旋转异构体，构想异构体和同分异构体的多羟基醛。葡萄糖在生物学领域具有重要地位，是活细胞的能量来源和新陈代谢中间产物。含糖聚合物(Glycopolymer)是一类具有良好生物兼容性的侧链含糖基的功能性聚合物,已广泛应用于药物传输、分子识别过程及人体器官组织相容性生物材料等方面。本论文旨在合成新型可用于开环移位聚合的含葡萄糖类聚合物单体，以7-氧杂降冰片烯单体为原料制备得到7-氧杂降冰片烯双丙烯酸衍生物以用作于开环易位聚合，再利用巯基-烯烃加成反应通过7-氧杂降冰片烯衍生物引入目标糖单元和功能基团，通过改变链接基团减少空间位阻效应，制备出含葡萄糖的聚合物单体。72211

毕业论文关键词：开环易位聚合；巯基-烯反应；迈克尔加成；ROMP；含糖聚合物

Married thiol-ene Michael addition with ROMP to synthesize glucose monomer   

Abstract: ： The Ring-Opening Metathesis Polymerization (ROMP) reaction is a method that is widely used to synthesize functionalized polymers at present。 In the past two decades, many scientists have explored about this。 Grubbs and other research and development of the Grubbs catalyst is often used as a catalyst for ROMP reaction, mainly because of its thermal stability is quite good and functional group tolerance is relatively strong, and get the product structure is also more clear and clear, and for ring tension The larger norbornene (NBE) monomer has relatively good reactivity as a catalyst。 While glucose is a polyhydroxyaldehyde having an optical isomer, a rotamer, a conformation isomer and an isomer。 Glucose in the field of biology has an important position,which is the energy source of living cells and metabolic intermediates。 Glycopolymer is a kind of functional biocompatible side chain containing sugar-based functional polymer,which has been widely used in drug delivery, molecular recognition process and human organ tissue compatibility of biological materials and so on。 The purpose of this paper is to synthesize a new type of glucose-containing polymer monomer which can be used for ring-opening shift polymerization。 The 7-oxa norbornene diacrylic acid derivative is prepared from 7-oxa norbornene monomer as In the open-loop metathesis polymerization, the target sugar units and functional groups were introduced through the 7-oxa-norbornene derivatives by the addition reaction of mercapto-olefins。 By reducing the steric hindrance effect by changing the linker groups, the glucose- Polymer monomer。

Keywords:  The Ring-Opening Metathesis Polymerization; ROMP; Michael addition; Married thiol-ene; glycopolymers

目  录

1。 前言1

1。1课题选择的背景和意义1

1。2烯烃反应反应1

1。2。1烯烃反应反应简介1

1。2。2烯烃反应反应机理2

1。2。3烯烃反应反应的主要类型3

1。3 开环易位聚合3

1。3。1开环易位聚合反应机理3

1。3。2活性开环易位聚合5

1。3。3 ROMP的催化剂发展5

1。3。4 ROMP的主要应用6

1。4 降冰片烯及其衍生物8

1。4。1降冰片烯的ROMP8

1。4。2降冰片烯衍生物的ROMP反应8

1。4。3降冰片烯衍生物的ROMP共聚8