摘要光学相干层析术(Optical Coherence Tomography, OCT)是利用生物组织的后向散射光与参考光发生弱相干来获得样品信息,是一种可以对生物组织实现非侵入式、高分辨率、高灵敏度的成像技术。频域光学相干层析技术是在传统OCT技术基础上发展而来的,具有更高的灵敏度和成像速度,因而频域OCT迅速成为目前OCT的热点之一。本论文先介绍了频域OCT的基本原理、优点,以及国内外最高速扫描成像的发展状况。然后对频域OCT系统中的振镜扫描系统进行了阐述。重点研究了高速实时3D成像OCT系统的扫描问题,包括超高速扫描、采集系统以及分辨率等重要参数。最后对目前的内窥OCT技术的发展进行了讨论。22402
关键词 频域光学相干层析术 高速扫描 振镜系统 内窥OCT 毕业论文设计说明书(论文)外文摘要
Title Study of experimental design of high-speed scanning device in spectral domain optical coherence tomography
Abstract
Optical coherence tomography (OCT) is based on the detection of the low coherence between the light backscattered from within tissue and reflected from the reference mirror of an interferometer and is a type of imaging mode that performs high-resolution optical sectional imaging non-invasively with high sensitivity at high speed. The spectral domain optical coherence tomography (SDOCT) is a development of the time domain optical coherence tomography. Because of its higher detection sensitivity and higher imaging speed, SDOCT becomes one of the front areas in the field. In this thesis, first of all, the basic principle, advantages and the development of high-speed scanning of SDOCT were described. Second,galvanometer system are then discussed with the emphasis on the high-speed scanning. Third part focuses on high-speed real-time 3D display system in high-speed SDOCT. Then ultra-high speed scanning part, the resolution the signal-to-noise ratio of SDOCT system are analyzed in detail. Finally the development of OCT endoscope was discussed.
Keywords Spectral domain optical coherence tomography High-speed scanning Galvanometer system Endoscopic OCT
目 次
目次 I
1 引言 1
1.1 OCT技术 1
1.1.1 OCT简介 1
1.1.2 OCT工作原理 2
1.1.3 时域与频域 4
1.2 OCT的重要参数 4
1.3 FDOCT的国内外发展状况 5
1.4 本课题的研究内容 6
2 高速扫描系统 7
2.1 电路设计 7
2.1.1 CTI公司6210H振镜控制 7
2.1.2 DAC控制板卡 10
2.1.3 单片机选型 10
2.1.4 CCD选型和数据采集卡 11
2.2 扫描采集系统的软件设计 11
2.2.1 CORTEX-M3开发环境和软件编写 11
2.2.2 DAC驱动设计 12
2.2.3 外部边沿触发采集卡自动采集设计 13
3 实时3D成像的OCT系统设计分析 15
3.1 系统设计分析 15
3.1.1 系统设置 15
3.1.2 光复解用器OD 16
3.1.3 数据处理系统设计 17
3.2 系统参数分析 18
3.2.1 成像速度 18
3.2.2 点扩散函数和纵向分辨率 19
3.2.3 光学放大和灵敏度 20