摘要水凝胶由于其很好的生物相容性、本身低毒性等被应用于生物医药、组织工程等领域。超分子相对于传统高分子而言，单体与单体是通过非共价键连接的，所以超分子水凝胶就有许多优良性能。组成水凝胶的超分子结构是水凝胶性质的重要影响因素，所以我们可以通过改变水凝胶超分子的结构来改变水凝胶的性能，从而满足实际生活中的应用。对于温敏型水凝胶，需要在超分子中引入具有温度响应的官能团，例如聚N-异丙基丙烯酰胺(PNIPAM)。pH响应型水凝胶主要是通过分子结构中亲疏水基团的亲疏水能力随着pH的不同而不同来实现水凝胶从凝胶到溶胶的转变，从而实现水凝胶对pH的敏感。88088

因此，我们要使水凝胶具有一些特殊性能就需要在分子结构中引入相应的基团。我们预计在主体分子中引入一个具有聚集诱导效应（AIE）荧光基团可以得到一种有荧光效应的超分子水凝胶，从而使得在凝胶聚集状态也能发出荧光，有效地避免了传统荧光基团的聚集诱导淬灭效应（ACQ）现象。为此，我们合成了一个中间以四苯基乙烯（TPE）基团为核，两端分别为β-环糊精（β-CD）基团的主体小分子，以及一个带有金刚烷官能团和三联吡啶基团的客体分子。由于β-CD的空腔大小与金刚烷分子的大小匹配，所以可以发生主客体反应，使主客体分子连接形成线型超分子，当线型分子的浓度到达一定值时，便可得到一种具有荧光效应的超分子水凝胶。

毕业论文关键词：水凝胶；超分子；合成；主客体反应；荧光

Abstract Hydrogels are widely used in biomedicine and tissue engineering because of their good biocompatibility and low toxicity。 Compared with the traditional polymer, the monomers are connected by non covalent bond。 Supramolecular structure composition of hydrogel is an important factor affecting the performance of hydrogel properties, so we can change the structure of the supramolecular hydrogel hydrogel to realize modification, so as to meet the application of real life。 For temperature sensitive hydrogels, it is necessary to introduce functional groups with a temperature response, such as poly (N- isopropyl acrylamide) (PNIPAM)。 The preparation of photosensitive hydrogels is usually introduce azobenzene groups in the molecular structure。 The pH responsive hydrogels are mainly based on the hydrophobic ability of hydrophobic groups in the molecular structure, which is different from the pH to achieve the transition from gel to sol, to realize the sensitivity of hydrogel to pH。 源-于,优W尔Y论L文.网wwW.youeRw.com 原文+QQ75201,8766

Therefore, in order to make hydrogels have some special properties, we need to introduce the corresponding groups in the molecular structure。 We expect the introduction of a main effect in the aggregation induced luminescence (AIE) for the molecular, so we can get a fluorescence effect of supramolecular hydrogel, which makes the state of aggregation in the gel can emit fluorescence, effectively avoid the aggregation induced quenching (ACQ) effect of traditional fluorophores  phenomenon。 To this end, we synthesized an intermediate with four phenyl ethylene (TPE) group as the core, both ends for beta cyclodextrin (β -CD) groups of the host small molecular, and with an adamantane functional group and terpyridyl groups of guest molecules。 The β-CD cavity size and adamantane molecular size matching, so the reaction is between guests and hosts, so that the main object of molecular connection form linear supramolecular, linear molecules when the concentration reaches a certain value, can be obtained with a fluorescence effect of supramolecular hydrogels

Keywords: hydrogel; supramolecular; synthesis; host-guest reaction; fluorescence 

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