摘    要硫代酰胺是一类非常重要的有机硫化合物，广泛地存在于具有生物活性的分子中。硫代酰胺是的常见有机基序在重要的生物和药物分子中发现例如氯乙酰，羟甲基硫内酰胺环噻啶等。同时，作为重要的组成部分，它们被广泛应用，构建了许多重要的含硫杂环，例如噻唑啉类，噻唑啉酮类，噻唑类，四唑类等等。其特点是易合成、无异味、易提纯并且稳定性高。由于硫原子的电负性核外电子的分布特点，使得这些化合物并性质较相应的酰胺活泼，具有多种多样的化学性质可进行一系列的转化反应，其在有机合成中也是重要的合成子，因此引起了广大有机合成工作者广泛的研究兴趣。这几年的研究成果表明，硫代酰胺类化合物可以抗炎、杀菌和抗结核。88714

本文介绍了近年来硫代酰胺的合成方法以及通过碳-氮、碳-硫键的构建来合成硫代酰胺化合物的方法；同时我们以芳香腈类化合物为原料，九水硫化钠为硫源，在DMF中高效的合成了硫代芳香苯甲酰胺类化合物，该方法具有原料便宜易得、简单高效、后处理简单等优点，存在一定的应用价值。

Thioamide which widely present in molecules with biological activity is a very important organic sulfur compound。Thioamide is a common organic motif that is found in important biological and drug molecules。 For example chloroacetyl, hydroxymethyl thiolactam cyclothiazide and so on。 At the same time,  is widely used to build a number of important sulfur-containing heterocycles as an important part for example thiazoles, thiazolinones, thiazoles, tetrazoles and so on 。 Thioamide is characterized by easy synthesis, no smell, easy to purify and high stability。 These compounds are more active than the corresponding amides and have a wide variety of chemical properties that can undergo a series of transformation reactions because of distribution characteristics of electrons in electronegatous nuclei of sulfur atoms。It is also an important synthesizer in organic synthesis, which has aroused extensive interest in the broad range of organic synthesis workers。 The results of the past few years show that thioamides can be anti-inflammatory, bactericidal and anti-tuberculosis。

This paper introduces the synthesis of thioamide in recent years and the method of synthesizing thioamide compounds by the construction of carbon-nitrogen and carbon-sulfur bonds: At the same time we use aromatic nitrile compounds as raw materials, sodium sulfate sulfide as sulfur source, in the efficient synthesis of DMF in the thio aromatic benzamide compounds, With the method has the advantages of cheap and easy to obtain raw materials, simple and efficient, simple post-processing, etc。, there is a certain application value。

毕业论文关键词：硫代酰胺； 碳-氮；碳-硫键；

    Keyword: Thioamide； carbon-nitrogen； carbon-sulfur bond 

 目录

第一章：前言 4

1。1概述 4

1。2硫代酰胺源Q于D优G尔X论V文Y网wwW.yOueRw.com 原文+QQ75201`8766 的性质 4

1。3硫代酰胺常用的合成方法 5

1。4 本课题的研究目的、意义和内容 11

第二章：合成硫代酰胺的方法探究 13

2。1引言 13

2。2 实验部分 14

2。2。1 仪器与试剂 14

2。2。2 实验步骤 14   

2。2。3结果与讨论 15

2。2。4 实验数据表征