摘要光反应途径制备及分离6，6-二溴甲基-2，2-联吡啶-4，4-二甲酸二甲酯摘要: 以6,6’-二甲基-2,2’-联吡啶-4,4’-二甲酸为原料，先通过酯化反应得到酯，然后直接通过光反应与NBS反应得到产品6,6’-二溴甲基-2,2’-联吡啶-4,4’-二甲酸二甲酯， 在实验中要考察不同相转移催化剂，催化剂的用量，反应温度，反应时间，不同的强酸及其用量对反应的影响从而得到最优反应条件，收率30%。经核磁共振，液相色谱等对分子结构进行表征，验证了合成方法的可靠性。该结构作为很重要的配位化合物，它不仅是癌症检测试剂和化工合成的中间体，而且由于其具有独特的螯合作用与镧系元素结合会形成具有优异的光物理性能的发光配合物。81215

毕业论文关键词： 6,6’-二溴甲基-2,2’-联吡啶-4,4’-二甲酸二甲酯；中间体；配位化合物

Preparation and Separation of 6,6'-Dibromomethyl -2,2'-Bipyridine-4,4'-Dimanedicarboxylate by Optical Reaction

Abstract: 6,6'-Dibromomethyl-2,2'-Bipyridine-4,4'-Dimanedicarboxylate was synthesized in two steps from  6,6'-methyl-2,2'-bipyridine-4,4'-dicarboxylic acid。 The first step was the preparation of 6,6'-methyl-2,2'-bipyridine-4,4'-dicarboxylate by esterification． The second step was to react with NBS to prepare the target product by Optical Reaction。 In the experiment, the effects of different phase transfer catalysts, catalyst dosage, reaction temperature, reaction time, different strong acids and their dosage on the reaction were investigated to obtain the optimum reaction conditions。 30% yield was achieved．The products were characterized by nuclear magnetic resonance( NMＲ),Liquid Chromatography to prove the reliability of the synthetic method．This structure is a very important coordination compound, It can not only be used as  intermediates  of  cancer detection reagent and chemical synthesis, but as a metal chelate ligand ，it can also be combined with lanthanides to form luminescent complexes with excellent photophysical properties。

KeyWords： 6,6'-Dibromomethyl- 2,2'-Bipyridine-4,4'-Dimanedicarboxylate；Intermediates  Coordination；Compounds

目录

1绪论 1

1。1 6,6’-二溴甲基-2,2’-联吡啶-4,4’-二甲酸二甲酯的概述 1

1。2 6,6’-二溴甲基-2,2’-联吡啶-4,4’-二甲酸二甲酯的国内外研究现状 3

1。3 6,6’-二溴甲基-2,2’-联吡啶-4,4’-二甲酸二甲酯的市场前景 4

1。4 本课题主要研究内容 4

2 6,6’-二溴甲基-2,2’-联吡啶-4,4’-二甲酸二甲酯的合成实验 5

2。1 材料试剂、仪器设备的使用 5

2。1。1 药品试剂 5

2。1。2 仪器设备 6

2。2 6,6’-二溴甲基-2,2’-联吡啶-4,4’-二甲酸二甲酯的合成 6

    2。2。1 实验前的预处理 6

2。2。2 6,6’-二甲基-2,2’-联吡啶-4,4’-二甲酸二甲酯的制备 6

2。2。3 6,6’-二溴甲基2,2’-联吡啶-4,4’-二甲酸二甲酯的制备 7

2。2。4 溶剂的回收利用 7

2。3 注意事项