摘要：介孔二氧化硅有序多孔，且孔道均匀易修饰，广泛运用于药物释放领域。本课题采用溶胶凝胶法制备介孔二氧化硅，并在此基础上进行磁性修饰得到比表面积较大，孔容易于调节的磁性介孔二氧化硅。同时使用了扫描电镜，透射电镜，红外，激光粒度仪对其进行了分析。在此基础上进行了空白介孔二氧化硅和磁性修饰后的介孔二氧化硅对抗癌药物DOX的装载，对比的进行了DOX的担载和释放实验并对修饰前后的微球中DOX的装载量、包封率及释放行为的变化做定性的分析。磁性修饰后的介孔二氧化硅不仅具有介孔二氧化硅的优点，同时还具有具有靶向性，对于药物的输送和释放有着重要的意义。 81790

毕业论文关键词：二氧化硅；磁性修饰；药物释放

Mesoporous Silica - loaded Microcapsule Surface Magnetic Orientation Modification

Abstract： Mesoporous silica nanomaterials caused widely attention in biomedical field due to their tunable pore sizes, the stability of the skeleton structure, easily modified internal and external surface and good biocompatibility, and their abundant pore can store a variety of drug molecules, which can be used in drug-controlled release。 However, along with the development of pharmacology, pathology and therapy method, the requirement of structure, function, size and composite for materials is urgent。 And the single function of pure mesoporous silica materials can not satisfy the needs already。 So, functional silica materials come into being, and studied widely。 Herein, we designed several magnetic mesoporous silica composites with different combination and structures, and investigated their favorable drug release properties。 In these composites, iron oxide with good biocompatibility, simple synthesis method and strong magnetism was chose as magnetic material。 And the textural, morphological and structural properties of the composites were carefully characterized by X-ray diffraction, transmission electron microscopy, scanning electron microscopy, respectively。 In addition, all the composites are employed as drug carries, and the delivery properties are measured by UV/Vis absorption spectroscopy in vitro and in human cells。

Key words：Silica；Magnetism；Drug delivery

目录

1绪论 1

1。1 引言 1

1。1。1 药物输送载体 1

1。1。2 药物载体的分类 2

1。2 介孔材料 3

1。2。1 介孔材料的研究进展 3

1。2。2 介孔材料的分类 3

1。3介孔二氧化硅的制备研究 4

1。3。1 溶胶凝胶法 4

1。3。2 水热合成法 4

1。3。3 低温合成法 5

1。3。4 表面沉积法 5

1。3。5 层层组装法 5

1。4 磁性修饰的介孔二氧化硅 6

1。5 本课题研究的目的及主要任务 6

1。5。1 主要目的 6

1。5。2 主要研究任务 7

2实验部分 8

2。1 实验所需药品和仪器 8

2。1。1 实验试剂 8

2。1。2 实验设备与仪器 8

2。2实验方法