摘要：介孔二氧化硅微球具有有序规则的介孔，目前在药物的运输和控释领域有着极大的发展潜力。本篇文章采用stöber法制备介孔二氧化硅纳米颗粒，并且通过壳聚糖修饰，得到具有高比表面积、高孔容积以及高孔隙率的性介孔二氧化硅-壳聚糖微球。通过电镜（TEM和SEM）、红外光谱分析了微球的化学基团。课题选取了抗癌药物—阿霉素（DOX）作为模型药物，将其包埋于制备的二氧化硅微球中形成一个载药微囊，对比了壳聚糖修饰前后的微球中DOX的装载量、包封率及释放行为的变化。通过药物释放实验，分析了壳聚糖修饰前后MSNs微球的不同pH环境下药物缓释的能力。结果发现，经壳聚糖修饰的MSNs微球具有更高的比表面积，更好的载药运输能力，为药物的缓控释提供了保障。80339

毕业论文关键词： 药物运输；二氧化硅；壳聚糖修饰；载药微囊；缓控释

Mesoporous silica/drug microcapsules environmental responsiveness modification

Abstract: Mesoporous silica microspheres have ordered mesopores, and they have great potential in the field of drug transport and controlled release。 In this paper, mesoporous silica nanoparticles were prepared by stöber method and modified by chitosan to obtain mesoporous silica-chitosan microspheres with high specific surface area, high pore volume and high porosity。 The chemical groups of the microspheres were analyzed by electron spectroscopy (TEM and SEM) and infrared spectroscopy。 (DOX) was used as a model drug, and it was embedded in the prepared silica microspheres to form a drug-loaded microcapsule。 The drug of DOX release behaviors from the microspheres were compared to analysis the effect of the chitosan’s modification。 Loading, entrapment efficiency and release behavior。 The ability of drug release in different pH environments of MSNs microspheres before and after chitosan modification was analyzed by drug release experiment。 The results showed that chitosan modified MSNs microspheres had higher specific surface area and better drug delivery ability, which provided the protection for drug release。

Key words: drug transport; silica; chitosan modification; drug loading microcapsules;

目  录

1 文献综述 4

1。1 引言 4

1。2 纳米药物载体的优势 4

1。3 介孔二氧化硅材料 5

1。4介孔二氧化硅材料的合成机理 6

1。5介孔二氧化硅制备工艺的研究进展 7

1。6溶胶-凝胶法及其优势 7

1。6。1溶胶-凝胶法 7

1。6。2溶胶-凝胶法优势 8

1。7 介孔二氧化硅纳米粒子药物传递系统研究进展 8

1。8 基于介孔二氧化硅的多功能纳米药物输送体系研究进展 9

1。9 pH响应药物输送体系研究进展 9

1。10 本课题的研究目的和研究意义 10

1。11 本课题的研究任务 10

1。12 本课题研究内容 11

2 实验部分 12

2。1 实验所需药品和仪器 12

2。1。1 实验材料和试剂 12

2。2。2 实验设备与仪器 12

2。2实验方法