表 4: 铑催化下Weinreb酰胺导向的烯烃偶联反应

2。3。1化合物的表征 

(2E,4Z)-Butyl 6-(methoxy(methyl)amino)-5-methyl-6-oxohexa-2,4-dienoate (3a)。 This compound was prepared by the general procedure described above and was obtained as an orange oil。 Yield = 80%。 1H NMR (500 MHz, CDCl3): δ 7。27 (dd, J = 15。0,11。5 Hz, 1H), 6。13 (d, J = 11。5 Hz, 1H), 5。89 (d, J = 15。0 Hz, 1H), 4。14 (t, J = 6。5 Hz, 2H), 3。61 (s, 3H), 3。26 (s, 3H), 2。08 (s, 3H), 1。66–1。60 (m, 2H), 1。39 (m, 2H), 0。94 (t, J = 7。5 Hz, 3H)。 13C NMR (125 MHz, CDCl3): δ 171。1, 166。7, 142。8, 140。1, 126。2, 122。1, 64。3, 61。8, 32。1, 31。1, 20。7, 19。1, 13。7。 HR-MS (ESI): calculated for C16H21NO4: [M+H]+  256。1543。 Found: m/z 256。1542。 FTIR (KBr, cm−1): ν 3507。68, 2957。85, 2932。54, 2857。87, 1715。65, 1652。43, 1634。89, 1273。67, 1147。72, 995。68。

(2E,4Z)-Butyl 6-(methoxy(methyl)amino)-5-hexyl-6-oxohexa-2,4-dienoate(3b)。This compound was prepared by the general procedure described above and was obtained as an orange oil, yield = 51%, 1H NMR (500 MHz, CDCl3): δ 7。30 (dd, J =15。0 Hz, 11。5 Hz, 1H), 6。12 (d, J = 11。5 Hz, 1H), 5。90 (d, J =15。0 Hz, 1H), 4。13 (t, J = 6。5 Hz, 2H), 3。57 (s, 3H), 3。27 (s, 3H),2。35 (t, J = 7。5 Hz, 2H), 1。60–1。66 (m, 2H), 1。47–1。53 (m, 2H), 1。25–1。42 (m, 8H), 0。94 (t, J = 7。5 Hz, 3H), 0。88 (t, J = 7。0 Hz,3H)。 13C NMR (125 MHz, CDCl3): δ 170。3, 166。8, 147。8, 140。4, 124。9, 122。2, 64。3, 61。7, 34。6, 32。1, 31。6, 30。7, 29。0, 27。5, 22。6,19。2, 14。1, 13。7。 HR-MS (ESI): calculated for C18H31NO4: [M+H]+ 326。2326。 Found: m/z 326。2332。 FTIR (KBr, cm−1): ν 3507。68, 2957。85, 2932。54, 2857。87, 1715。65, 1652。43, 1634。89, 1455。86, 1385。22, 1273。67, 1147。72, 995。68。