摘    要苯并咪唑类化合物是一种含有两个氮原子的苯并杂环化合物，苯并咪唑类化合物衍生物具有良好的生物活性。而且是一种很重要的中间体。苯并咪唑类化合物呈现出广泛的生物活性,如抗寄生虫、抗菌、抗高血压、抗病毒、镇痛等。近年来关于糖基含杂环的例子报道也越来越多，在苯并咪唑的基础上，将利用葡萄糖为糖基，通过环合反应合成葡萄糖基苯并咪唑类化合物，且本论文研究了为增加苯并咪唑的活性，用葡萄糖为糖基修饰合成糖基化苯并咪唑类化合物的研究，进而使苯并咪唑类化合物活性杂环分子进一步提高、毒副作用大大降低、水溶性得到更好的改善等优点而成为研究的热点。有不少新的糖苷药物在近年来不断涌现。88472

本论文主要研究了葡萄糖苯并咪唑类化合物的合成方法，通过活性测试，筛选出了部分有较好的抗肿瘤活性的新化合物。为进一步研究葡萄糖基苯并咪唑类化合物的生物活性奠定了一定的基础。

Benzene and imidazole compounds are a kind of benzene with two nitrogen atoms and heterocyclic compounds, benzene and imidazole derivatives have good biological activity。 It is an important intermediate。 Benzene and imidazole compounds exhibit a wide range of bioactivity, such as anti-parasite, antibacterial, antihypertensive, antiviral, analgesic and so on。 In recent years, more and more examples of sugar-based heterocyclic rings are reported, On the basis of benzene and imidazole, glucose is used as a sugar-base, the synthesis of glycosyl benzimidazoles compounds through the cyclic reaction, and the study of the addition of benzimidazoles activity, Study on the synthesis of chitosan-based benzimidazoles compounds with glucose as a modified glycosyl, Further enhancement of active heterocyclic molecules of benzene and imidazole compounds, the toxic side effects and better water solubility have become the hotspot of research。 Many new Aminoglycoside drugs have emerged in recent years。

This paper mainly studies the synthesis method of the glucose benzene and imidazole compounds。 Through the activity test, the new compounds that have better antitumor activity are screened out。 To further study the bioactivity of glucose-based benzimidazoles compounds, a certain foundation was established。

毕业论文关键词：苯并咪唑；糖基；合成；葡萄糖

Keyword: Benzimidazoles；glycosyl；Synthesis；glucose 

目    录

引言 ··4

   1。实验背景概述··5

        1。1 苯并咪唑类化合物的性质与应用···5

            1。2利用邻苯二胺源Y于Y优E尔Y论L文W网wwW.yOueRw.com 原文+QQ752018.766 作为原料制备苯并咪唑类化合物···5

        1。3糖氧苷键化学制备方法的研究·7

1。4糖基含氮杂环化合物构建方法的研究···8

   2。实验部分··8

        2。1 实验试剂和仪器·8

            2。1。1 实验仪器·8

            2。1。2 实验试剂·9

        2。2 实验过程···9

            2。2。1全乙酰β-D-葡萄糖的制备···9

            2。2。2溴代全乙酰β-D-葡萄糖的制备··10

            2。2。3全乙酰β-D-葡萄糖基苯甲醛的制备··10

2。2。4全乙酰β-D-葡萄糖基苯并咪唑的制备11