Put  3 - methoxy acrolein with cyano acetic acid armour grease 40 hours after stirring at room temperature, the soluble in methanol, stir in sodium hydroxide solution, hydrochloric acid acidification again can get the target product。 

The abnormal route is simple, the product yield and quality score is very high also, but 3 - methoxy acrolein is very rare material, so, the best synthetic route is only theory, is not suitable for industrial production。 

（8）1, 3 - dichloropropylene is the raw material 

Cyano acetic ester chloride and 1, 3 - dichloro propylene reaction after 8 h to 2, 5 - dichloro - 2 - cyano - 4 - pentene acid ester, yield was 55。1%, and then using the closed-loop response system to its release HCl, the yield was 45。3%, 2 - nicotinic acid chloride by sodium hydroxide hydrolysis。 

Route of the craft is simple, mild reaction conditions, suitable for operation, test, 5 - dichloro - 2-2 cyano - 4 - pentene acid ester preparation and closed loop using the one-pot process, is beneficial to industrialized production, but the yield of each step is too low, relatively high cost, not suitable for industrial production。 

（9）Propylene dialdehyde and ethyl acetic acid ethyl acetate ring 

Propylene glyoxal and ethyl acetic acid ethyl acetate with a closed loop in lewis acid, and then hydrolyzed by 2-chloric acid in alkaline conditions。 

The route is simple, the product is selective, but the reaction time is long, and it is very rare, expensive, and not suitable for large-scale industrial production。 

By comparing the above synthesis route, this topic decided according to the Liu Junan xiao-lei wei test results, use in 3 - cyanopyridine and hydrogen peroxide as the starting material, 3 - cyanopyridine N oxide generated by oxidation, and then generate chlorine - 2-3 - cyanopyridine chloride, finally generate 2 - chlorine nicotinic acid via hydrolysis design capacity of 100 tons of 2 - nicotinic acid chloride process。 

The source of the task 

This design for the annual output of 100 tons of 2 - nicotinic acid chloride process design research, based on the professional basic course of study, design reasonable process flow, select the corresponding process equipment, etc。 Introduces the performance of 2 - chlorine niacin, main USES, production status and developing trend, and determine to 3 - cyanopyridine as raw material after oxidation reaction, chlorination and hydrolysis reaction of cyano design research of this technology。 In the design process, according to the requirement of the design specification, through the material balance, process parameters and consumption process indicators to determine equipment, at the same time for 2 - nicotinic acid chloride synthesis security considerations and the "three wastes" treatment has made the related instructions。 The corresponding design drawings are drawn, including process flowchart, main equipment drawing, equipment layout, etc。 

design standard

This design references the following national standards and regulations :

（1）The classification and code of dangerous and hazardous factors in the production process 

（2）The classification criteria for dangerous chemistry 

（3）The classification of the chemical medium and the risk of explosion hazard in the pressure vessel 

（4） Factory fire prevention regulation 

（5）The regulations on the comprehensive discharge of sewage 

（6）steel pressure vessels

（7）Shell heat exchanger standard 

（8）Design and design of process system equipment 

（9）Rules for the layout of chemical installations 

Key Words: 2-chloronicotinic Acid; 3-cyanopyridine; technological design; material balance

目录

1 绪论